1-hydroxy-2-naphthoate hydroxylase
| 1-hydroxy-2-naphthoate hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.135 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
1-hydroxy-2-naphthoate hydroxylase (EC 1.14.13.135, 1-hydroxy-2-naphthoic acid hydroxylase) is an enzyme with systematic name 1-hydroxy-2-naphthoate,NAD(P)H:oxygen oxidoreductase (2-hydroxylating, decarboxylating).[1] This enzyme catalyses the following chemical reaction
The four substrates of this enzyme are 1-hydroxy-2-naphthoic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are 1,2-naphthalenediol, oxidised NAD+, water, and carbon dioxide.[2] It is involved in chrysene degradation in some bacteria.[3]
References
- ↑ Deveryshetty J, Phale PS (October 2010). "Biodegradation of phenanthrene by Alcaligenes sp. strain PPH: partial purification and characterization of 1-hydroxy-2-naphthoic acid hydroxylase". FEMS Microbiology Letters. 311 (1): 93–101. doi:10.1111/j.1574-6968.2010.02079.x. PMID 20727010.
- ↑ Enzyme 1.14.13.135 at KEGG Pathway Database.
- ↑ Nayak AS, Sanjeev Kumar S, Santosh Kumar M, Anjaneya O, Karegoudar TB (July 2011). "A catabolic pathway for the degradation of chrysene by Pseudoxanthomonas sp. PNK-04". FEMS Microbiology Letters. 320 (2): 128–34. doi:10.1111/j.1574-6968.2011.02301.x. PMID 21545490.
External links
- 1-hydroxy-2-naphthoate+hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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