1,2,3-Tris(4-hydroxybutyroyloxy)propane

1,2,3-Tris(4-hydroxybutyroyloxy)propane
Clinical data
Drug class	GABAB receptor agonist; GHB receptor agonist; Hypnotic
ATC code	None;
Identifiers
	IUPAC name 2,3-bis(4-hydroxybutanoyloxy)propyl 4-hydroxybutanoate;
PubChem CID	53806632;
Chemical and physical data
Formula	C15H26O9
Molar mass	350.364 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CC(=O)OCC(COC(=O)CCCO)OC(=O)CCCO)CO;
	InChI InChI=1S/C15H26O9/c16-7-1-4-13(19)22-10-12(24-15(21)6-3-9-18)11-23-14(20)5-2-8-17/h12,16-18H,1-11H2; Key:FMEHQSVBVKIXBB-UHFFFAOYSA-N;

1,2,3-Tris(4-hydroxybutyroyloxy)propane is a chemical compound which acts as a sustained-release prodrug for gamma-hydroxybutyrate (GHB), consisting of three molecules of gamma-hydroxybutyrate joined to a glycerol core by readily metabolised ester links. It was developed as a potential agent for the treatment of sleep disorders such as narcolepsy.^[1]

References

↑ US 7572605, Mamelak M, Houghton WC, Reardan DT, Miller BL, "Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers", published 2005-07-18, issued 2009-08-11, assigned to Orphan Medical Inc and Jazz Pharmaceuticals Inc