(S)-norcoclaurine synthase
| (S)-norcoclaurine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.99.14 | ||||||||
| CAS no. | 79122-01-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme (S)-norcoclaurine synthase (EC 3.5.99.14) catalyzes the chemical reaction:[1][2]
- 4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (Dopamine) (S)-norcoclaurine + H2O
-norcoclaurine_synthesis.svg.png)
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in isoquinoline alkaloid biosynthesis.[3]
References
- ↑ Stadler R, Kutchan TM, Zenk MH (1989). "(S)-norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis". Phytochemistry. 28 (4): 1083–1086. doi:10.1016/0031-9422(89)80187-6.
- ↑ Samanani N, Facchini PJ (September 2002). "Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". The Journal of Biological Chemistry. 277 (37): 33878–33883. doi:10.1074/jbc.M203051200. PMID 12107162.
- ↑ Tian Y, Kong L, Li Q, Wang Y, Wang Y, An Z, et al. (November 2024). "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids". Natural Product Reports. 41 (11): 1787–1810. doi:10.1039/d4np00029c. PMID 39360417.
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