Zinc finger protein 674

ZNF674
Identifiers
Aliases	ZNF674, MRX92, ZNF673B, zinc finger protein 674
External IDs	OMIM: 300573; GeneCards: ZNF674
Gene location (Human) Chr. X chromosome (human) Band Xp11.3 Start 46,497,725 bp End 46,545,457 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle Achilles tendon ganglionic eminence epithelium of colon ventricular zone stromal cell of endometrium muscle of thigh islet of Langerhans monocyte n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 641339 n/a Ensembl ENSG00000251192 n/a UniProt Q2M3X9 n/a RefSeq (mRNA) NM_001039891 NM_001146291 NM_001190417 n/a RefSeq (protein) NP_001034980 NP_001139763 NP_001177346 n/a Location (UCSC) Chr X: 46.5 – 46.55 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Zinc finger protein 674 is a protein that in humans is encoded by the ZNF674 gene.

Function

This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.