ZC4H2

ZC4H2
Identifiers
Aliases	ZC4H2, HCA127, KIAA1166, WRWF, WWS, zinc finger C4H2-type containing, MRXS4, MCS, WRWFFR
External IDs	OMIM: 300897; MGI: 2679294; GeneCards: ZC4H2
Gene location (Human) Chr. X chromosome (human) Band Xq11.2 Start 64,915,802 bp End 65,034,713 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X C3 Start 94,682,799 bp End 94,702,115 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone prefrontal cortex muscle layer of sigmoid colon popliteal artery tibial arteries stromal cell of endometrium C1 segment Descending thoracic aorta islet of Langerhans Top expressed in superior cervical ganglion medial ganglionic eminence hand genital tubercle trigeminal ganglion tail of embryo otolith organ ventricular zone utricle primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component cytoplasm cell junction postsynaptic membrane plasma membrane synapse nucleus membrane Biological process multicellular organism development spinal cord motor neuron differentiation neuromuscular junction development nervous system development positive regulation of neuron differentiation cell differentiation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 55906 245522 Ensembl ENSG00000126970 ENSMUSG00000035062 UniProt Q9NQZ6 Q68FG0 RefSeq (mRNA) NM_001178032 NM_001178033 NM_001243804 NM_018684 NM_001003916 NM_001289696 NM_001289697 RefSeq (protein) NP_001171503 NP_001171504 NP_001230733 NP_061154 NP_001003916 NP_001276625 NP_001276626 Location (UCSC) Chr X: 64.92 – 65.03 Mb Chr X: 94.68 – 94.7 Mb PubMed search
Wikidata
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Zinc finger C4H2 domain-containing protein is a protein which in humans is encoded by the gene ZC4H2 gene. The ZC4H2 protein is involved in nervous system development, and in particular the development of major noradrenaline-producing neuron regions such as the locus coeruleus. The ubiquitin ligase, RNF220, and ZC4H2 form a complex which monoubiquitinates the proteins PHOX2A and PHOX2B, which increases their DNA-binding ability.

See also

• Wieacker syndrome
• ZC4H2-associated rare disorders

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.