Xylono-1,4-lactonase
| xylono-1,4-lactonase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.68 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme xylono-1,4-lactonase (EC 3.1.1.68) catalyzes the reaction
D-xylono-1,4-lactone
H2O
H2O
D-xylonic acid
The enzyme characterised from Pseudomonas fragi and Gluconobacter oxydans hydrolyses D-xylono-1,4-lactone to D-xylonic acid.[1][2][3] The enzyme is of interest as a target for metabolic engineering.[4]
This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name of this enzyme class is D-xylono-1,4-lactone lactonohydrolase. Other names in common use include xylono-γ-lactonase, and xylonolactonase.[5]
References
- ↑ Buchert, Johanna; Viikari, Liisa (1988). "The role of xylonolactone in xylonic acid production by Pseudomonas fragi". Applied Microbiology and Biotechnology. 27 (4). doi:10.1007/bf00251763.
- ↑ Buchert, Johanna; Viikari, Liisa (1988). "Oxidative D-xylose metabolism of Gluconobacter oxydans". Applied Microbiology and Biotechnology. 29 (4): 375–379. doi:10.1007/BF00265822.
- ↑ Schomburg, Dietmar; Stephan, Dörte (1998). "Xylono-1,4-lactonase". Enzyme Handbook 15. pp. 57–59. doi:10.1007/978-3-642-58948-5_14. ISBN 978-3-540-64116-2.
- ↑ Avci, Fatma Gizem; Prasun, Tim; Wendisch, Volker F. (2025). "Metabolic engineering for microbial production of sugar acids". BMC Biotechnology. 25 (1) 36. doi:10.1186/s12896-025-00973-7. PMC 12076931. PMID 40361067.
- ↑ Enzyme 3.1.1.68 at KEGG Pathway Database.
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