| XAGE1B |
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| Identifiers |
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| Aliases | XAGE1B, CT12.1, CT12.1C, CT12.1D, CT12.1E, CTP9, GAGED2, XAGE-1, XAGE1, XAGE1C, XAGE1D, X antigen family member 1E, X antigen family member 1B, XAGE1E, CT12.1b |
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| External IDs | OMIM: 300289, 300744, 300745; GeneCards: XAGE1B |
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| Wikidata |
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X antigen family member 1B (also somewhat ambiguously called XAGE-1) is a protein that in humans is encoded by the XAGE1B gene.[3] The XAGE1B gene encodes a protein which is typically identical to the protein encoded by its paralog, XAGE1A.[4] This shared protein is often referred to as XAGE-1, when not specifying the origin gene.[4]
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.[3]
Further reading
- Brinkmann U, Vasmatzis G, Lee B, Pastan I (April 1999). "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database". Cancer Research. 59 (7): 1445–8. PMID 10197611.
- Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I (September 2000). "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma". Cancer Research. 60 (17): 4752–5. PMID 10987281.
- Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ, van Muijen GN (January 2002). "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis". International Journal of Cancer. 97 (2): 195–204. doi:10.1002/ijc.1584. PMID 11774264. S2CID 36598913.
- Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ, Van Muijen GN (May 2002). "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma". International Journal of Cancer. 99 (3): 361–9. doi:10.1002/ijc.10371. PMID 11992404. S2CID 45958151.
- Egland KA, Kumar V, Duray P, Pastan I (May 2002). "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers". Molecular Cancer Therapeutics. 1 (7): 441–50. PMID 12479262.
- Lim JH, Kim SP, Gabrielson E, Park YB, Park JW, Kwon TK (August 2005). "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation". International Journal of Cancer. 116 (2): 200–6. doi:10.1002/ijc.21007. PMID 15800911. S2CID 25575235.
- Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M, et al. (August 2005). "XAGE-1 expression in non-small cell lung cancer and antibody response in patients". Clinical Cancer Research. 11 (15): 5496–503. doi:10.1158/1078-0432.CCR-05-0216. PMID 16061866. S2CID 8514961.
- Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K, et al. (March 2007). "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors". Cancer Immunity. 7: 5. PMC 2935747. PMID 17335148.
