WDR45L

WDR45B
Identifiers
Aliases	WDR45B, WDR45L, WIPI-3, WIPI3, WD repeat domain 45B, NEDSBAS
External IDs	OMIM: 609226; MGI: 1914090; GeneCards: WDR45B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,648,553 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	121,245,271 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; epithelium of nasopharynx; ; beta cell; ; right uterine tube; ; mucosa of pharynx; ; nasal epithelium; ; gingival epithelium; ; epithelium of bronchus; ; skin of arm; ; bronchial epithelial cell;
	Top expressed in
	epiblast; ; neural tube; ; ovary; ; mesencephalon; ; placenta; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; ventricular zone; ; ganglionic eminence; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding; protein binding; TSC1-TSC2 complex binding; lipid binding;
Cellular component	cytosol; extrinsic component of membrane; phagophore assembly site membrane; phagophore assembly site; lysosome;
Biological process	protein lipidation; protein localization to phagophore assembly site; autophagy of mitochondrion; autophagy of nucleus; autophagosome assembly; cellular response to starvation; autophagy;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56270
	66840
	ENSG00000141580
	ENSMUSG00000025173
	Q5MNZ6
	Q9CR39
	NM_019613
	NM_025793
	NP_062559
	NP_080069
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like, is a protein that in humans is encoded by the gene WDR45B (previously WDR45L).^[5]

Structure and function

WIPI-3 is a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein–protein interactions, and a conserved motif for interaction with phospholipids.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141580 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025173 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: WDR45-like".

Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Jeffries TR, Dove SK, Michell RH, Parker PJ (2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
Proikas-Cezanne T, Waddell S, Gaugel A, et al. (2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141580 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025173 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: WDR45-like".

[1]

[2]

[3]

[4]

[5]

WDR45L

Structure and function

See also

References

Further reading