WASH complex subunit 3

WASHC3
Identifiers
Aliases	WASHC3, CGI-116, CCDC53, coiled-coil domain containing 53, WASH complex subunit 3
External IDs	MGI: 1914532; GeneCards: WASHC3
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.2 Start 102,012,840 bp End 102,062,149 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 88,201,093 bp End 88,246,158 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis Achilles tendon decidua C1 segment sperm tibial arteries left coronary artery Descending thoracic aorta right coronary artery Top expressed in lens morula epithelium of lens intercostal muscle sternocleidomastoid muscle blastocyst triceps brachii muscle seminiferous tubule umbilical cord endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component endosome early endosome WASH complex Biological process protein transport biological process exocytosis actin filament polymerization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51019 67282 Ensembl ENSG00000120860 ENSMUSG00000020056 UniProt Q9Y3C0 Q9CR27 RefSeq (mRNA) NM_001301107 NM_016053 NM_001122960 NM_026070 NM_027487 RefSeq (protein) NP_001288036 NP_057137 NP_001116432 NP_080346 NP_081763 Location (UCSC) Chr 12: 102.01 – 102.06 Mb Chr 10: 88.2 – 88.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

WASH complex subunit 3 is a protein that in humans is encoded by the WASHC3 gene (previously CCDC53). As its name suggests, the WASHC3 protein is part of the core of the WASH regulatory complex, together with WASH (WASHC1, WASH2P or WASH3P), WASHC2 (A or C), WASHC4, and WASHC5.. It is predicted to be involved in the transport out of the cells via exocytosis.

External links

• Human CCDC53 genome location and CCDC53 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.