Verducatib

Verducatib
Clinical data
Other names	BI-1291583
Identifiers
	IUPAC name (1R,3S,4S)-N-[(1S)-1-cyano-2-[2-fluoro-4-[1'-(oxetan-3-yl)spiro[1H-2-benzofuran-3,4'-piperidine]-5-yl]phenyl]ethyl]-2-azabicyclo[2.2.1]heptane-3-carboxamide;
CAS Number	1887236-33-0;
PubChem CID	118939917;
ChemSpider	129001882;
UNII	LPO8EV0QNS;
ChEMBL	ChEMBL5942494;
Chemical and physical data
Formula	C31H35FN4O3
Molar mass	530.644 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C[C@@H]2C[C@H]1[C@H](N2)C(=O)N[C@@H](CC3=C(C=C(C=C3)C4=CC5=C(COC56CCN(CC6)C7COC7)C=C4)F)C#N;
	InChI InChI=InChI=1S/C31H35FN4O3/c32-28-14-20(1-3-21(28)11-25(15-33)35-30(37)29-22-5-6-24(12-22)34-29)19-2-4-23-16-39-31(27(23)13-19)7-9-36(10-8-31)26-17-38-18-26/h1-4,13-14,22,24-26,29,34H,5-12,16-18H2,(H,35,37)/t22-,24+,25-,29-/m0/s1; Key:MIBKKDLVBYJWTB-AIKBEYBBSA-N;

Verducatib is an investigational new drug that is being evaluated by Boehringer Ingelheim for the treatment of bronchiectasis.^[1] It is a cathepsin C inhibitor.^[1]^[2]

References

1 2 "Verducatib". AdisInsight. Springer Nature Switzerland AG. Retrieved 5 July 2026.
↑ Flume PA, Maselli DJ (March 2026). "Bronchiectasis Treatment Goals, Unmet Needs, and Emerging Therapies: A Podcast". Pulmonary Therapy. 12 (1): 1–12. doi:10.1007/s41030-025-00330-1. PMC 12992775. PMID 41269659.