Ureidoglycolate dehydrogenase

ureidoglycolate dehydrogenase
Identifiers
EC no.1.1.1.154
CAS no.62213-62-1
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, ureidoglycolate dehydrogenase (EC 1.1.1.154) is an enzyme that catalyzes the chemical reaction

2D representation of the chemical structure of Q27089426.
(-)-ureidoglycolic acid
+ NAD+
 
 
 
H+
Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right
 
H+
 
2D representation of the chemical structure of Q27101984.
oxaluric acid
+ NADH
 

The two substrates of this enzyme are (-)-ureidoglycolic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are oxaluric acid, reduced NADH, and a proton. This enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)+ oxidoreductase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1WTJ​ and PDB: 1XRH​.

References

  1. ↑ Enzyme 1.1.1.154 at KEGG Pathway Database.
  2. ↑ van der Drift C, van Helvoort PE, Vogels GD (1971). "S-ureidoglycolate dehydrogenase: purification and properties". Arch. Biochem. Biophys. 145 (2): 465–9. doi:10.1016/S0003-9861(71)80006-1. PMID 4399430.


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