UNC93B1

UNC93B1
Identifiers
Aliases	UNC93B1, IIAE1, UNC93, UNC93B, Unc-93B1, unc-93 homolog B1 (C. elegans), unc-93 homolog B1, TLR signaling regulator
External IDs	OMIM: 608204; MGI: 1859307; GeneCards: UNC93B1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,004,982 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,999,340 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; olfactory zone of nasal mucosa; ; spleen; ; bone marrow cell; ; appendix; ; right lung; ; right uterine tube; ; upper lobe of left lung; ; minor salivary glands;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; mesenteric lymph nodes; ; spleen; ; tibiofemoral joint; ; calvaria; ; ankle joint; ; ankle; ; submandibular gland; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	Toll-like receptor binding;
Cellular component	integral component of membrane; early phagosome; Golgi membrane; endosome; lysosome; phagocytic vesicle; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; cytoplasmic vesicle;
Biological process	toll-like receptor 9 signaling pathway; intracellular protein transport; toll-like receptor 3 signaling pathway; adaptive immune response; defense response to virus; toll-like receptor 7 signaling pathway; toll-like receptor signaling pathway; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81622
	54445
	ENSG00000110057
	ENSMUSG00000036908
	Q9H1C4
	Q8VCW4
	NM_030930
	NM_001161428; NM_019449
	NP_112192
	NP_001154900; NP_062322
	Wikidata
View/Edit Human	View/Edit Mouse

Unc-93 homolog B1 (C. elegans), also known as UNC93B1, is a protein which in humans is encoded by the UNC93B1 gene.^[5]^[6]

Function

This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm.^[5]

In humans, UNC93B1 is involved in interferon production. Mutations in UNC93B1 have been associated with an innate immune defect that increases susceptibility to encephalitis caused by herpes simplex virus.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000110057 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036908 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: UNC93B1 unc-93 homolog B1 (C. elegans)".
↑ Kashuba VI, Protopopov AI, Kvasha SM, Gizatullin RZ, Wahlestedt C, Kisselev LL, et al. (January 2002). "hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein". Gene. 283 (1–2): 209–217. doi:10.1016/S0378-1119(01)00856-3. PMID 11867227.
↑ Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, et al. (October 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797). New York, N.Y.: 308–312. doi:10.1126/science.1128346. PMID 16973841.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Arnlöv J, Sundström J, Lind L, Andrén B, Andersson M, Reneland R, et al. (October 2005). "hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men". European Journal of Heart Failure. 7 (6): 958–965. doi:10.1016/j.ejheart.2004.06.009. PMID 16111919. S2CID 22339419.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000110057 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036908 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: UNC93B1 unc-93 homolog B1 (C. elegans)".

[Kashuba_2002-6] Kashuba VI, Protopopov AI, Kvasha SM, Gizatullin RZ, Wahlestedt C, Kisselev LL, et al. (January 2002). "hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein". Gene. 283 (1–2): 209–217. doi:10.1016/S0378-1119(01)00856-3. PMID 11867227.

[7] Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, et al. (October 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797). New York, N.Y.: 308–312. doi:10.1126/science.1128346. PMID 16973841.

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Function

References

Further reading