Tyramine N-methyltransferase
| Tyramine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.27 | ||||||||
| CAS no. | 37256-96-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tyramine N-methyltransferase (EC 2.1.1.27) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which tyramine is converted to N-methyltyramine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH).[1]
The enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tyramine N-methyltransferase. Other names in common use include DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid), S-adenosyl-methionine:tyramine N-methyltransferase, and tyramine methylpherase. This enzyme participates in tyrosine metabolism.[2]
References
- ↑ Mann JD, Mudd SH (1963). "Alkaloids and plant metabolism. IV. The tyramine methylpherase of barley roots". J. Biol. Chem. 238: 381–385. doi:10.1016/S0021-9258(19)84008-5.
- ↑ Enzyme 2.1.1.27 at KEGG Pathway Database.
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