Tryptophan 2-C-methyltransferase
| Tryptophan 2-C-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.106 | ||||||||
| CAS no. | 126626-83-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tryptophan 2-C-methyltransferase (EC 2.1.1.106) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the natural amino acid, L-tryptophan, is converted to 2-methyl-L-tryptophan. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme characterised from Streptomyces laurentii is part of the biosynthetic pathway to thiostrepton.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase. Other names in common use include tryptophan 2-methyltransferase, and S-adenosylmethionine:tryptophan 2-methyltransferase.[2]
References
- ↑ Frenzel T, Zhou P, Floss HG (1990). "Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase". Arch. Biochem. Biophys. 278 (1): 35–40. doi:10.1016/0003-9861(90)90227-P. PMID 2321967.
- ↑ Enzyme 2.1.1.106 at KEGG Pathway Database.
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