Tropinesterase
| Tropinesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.10 | ||||||||
| CAS no. | 59536-71-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tropinesterase (EC 3.1.1.10) is an enzyme that catalyzes the reaction
The enzyme first characterised from rabbit liver hydrolyses the alkaloid, atropine into tropine and tropic acid.[1][2][3] the enzyme has also been found in the plant Duboisia myoporoides.[4]
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is atropine acylhydrolase. Other names in common use include tropine esterase, atropinase, and atropine esterase.[5]
In animals
Plasma atropinesterase exhibits high enantiospecific activity only in some rabbits; in the remaining individuals, as well as in dogs, goats, guinea pigs, pigs, rhesus macaques, and humans, only background hydrolysis of an unknown substrate is recorded.[6]
References
- ↑ Glick D, Glaubach S, Moore DH (1942). "Azolesterase activities of electrophoretically separated proteins of serum". J. Biol. Chem. 144 (2): 525–528. doi:10.1016/S0021-9258(18)72538-6.
- ↑ Moog P, Krisch K (1974). "[The purification and characterization of atropine esterase from rabbit liver microsomes (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 355 (5): 529–42. PMID 4435736.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "Tropinesterase". Enzyme Handbook 3. pp. 55–58. doi:10.1007/978-3-642-76463-9_9. ISBN 978-3-642-48962-4.
- ↑ Kitamura, Yoshie; Miura, Hiroshi; Sugii, Michiyasu (1988). Change of Atropine Esterase Activity in the Regenerated Plants of Duboisia myoporoides during Development, and its Relation to Alkaloid Accumulation. Vol. 133. pp. 316–319. doi:10.1016/S0176-1617(88)80207-4.
- ↑ Enzyme 3.1.1.10 at KEGG Pathway Database.
- ↑ Harrison, Patrick K.; Tattersall, John E. H.; Gosden, Ed. "The presence of atropinesterase activity in animal plasma". Naunyn-Schmiedeberg's Archives of Pharmacology. 373 (3): 230–236. doi:10.1007/s00210-006-0054-5. ISSN 0028-1298. PMID 16736160.