Trese Leinders-Zufall

Trese Leinders-Zufall
Trese Leinders-Zufall
Born
Trese Leinders
Scientific career
ThesisEffects of divalent cations on calcium-activated potassium channels (1992)

Trese Leinders-Zufall née Leinders (born January 19, 1963) is a Dutch physiologist and professor at the Center for Integrative Physiology and Molecular Medicine at the Saarland University, Germany. She is a faculty member in the Department of Physiology at the Faculty of Medicine. She is known for her research investigating the olfactory system. Her work focuses on the mechanisms of odor and pathogen perception, the neural pathways that mediate olfactory-encoded social behaviors, and the function of TRP channels in the neurons of the olfactory, respiratory, and central nervous systems.[1][2][3]

Education and career

Leinders-Zufall received her first training in Biology at the Utrecht University in the Netherlands, and earned her degree in 1992. She was a postdoctoral fellow and later an associate research scientist at Yale University from 1992 until 1997 in the Department of Neurology (Stephen G. Waxman) and the Department of Neurobiology (Gordon M. Shepherd). Leinders-Zufall accepted a position of assistant professor at University of Maryland, Baltimore in 1997, and was promoted to associate professor in 2002. In 2008 she received an endowed Lichtenberg Professorship from the Volkswagen Foundation in Germany, and accepted a full professorship at the Department of Physiology, Saarland University, Campus Homburg, where the School of Medicine is located.[4] This endowed professorship has allowed her to establish an internationally recognized research program in Germany, positioned at the interface between the nervous-, endocrine- and immune systems.[1][5][3]

Research

Leinders-Zufall is known for her work on olfactory systems,[6][2] neural pathways mediating olfactory-encoded innate social behaviors,[7] and investigations into various TRP channel subtypes.[1][8] Early in her career, she studied calcium-activated potassium channels.[9][10]

Leinders-Zufall mainly studies the basic molecular and cellular processes that allow animals to communicate through chemicals. She studies the mechanisms that control complex behaviors, such as aggression,[11] parental care,[12] and reproduction.[1] Her main focus is on signal transduction cascades and ion channels that are controlled by second messengers.[8][10][13][14] She uses many different advanced methods in electrophysiology, calcium imaging, and photopharmacology.[13][10]

A series of fundamental studies of odor transduction was produced by the combined effort of Gordon M. Shepherd, Stuart Firestein, Frank Zufall, Charles A. Greer and Trese Leinders-Zufall: "This included inhibition of the CNG channels by intracellular calcium,[15] and modulation of the CNG channels by carbon monoxide[14] and by cyclic GMP."[16] Then, Leinders-Zufall went on to identify odor-induced calcium transients in single olfactory cilia.[17][18] Leinders-Zufall's research has contributed significantly to our understanding of the mechanisms underlying chemosensation (exteroception)[19][5][6] and interoception,[1][11] and of the connections between these mechanisms and the nervous system.[20]

Awards and honors

Key papers

  • Leinders-Zufall, Trese; Greer, Charles A.; Shepherd, Gordon M.; Zufall, Frank (1998-08-1) "Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction". J Neurosci. 18 (15):5630-9. PMID 9671654 doi:10.1523/JNEUROSCI.18-15-05630.1998
  • Leinders-Zufall, Trese; Lane, Andrew P.; Puche, Adam C.; Ma, Weidong; Novotny, Milos V.; Shipley, Michael T.; Zufall, Frank (2000-06-15). "Ultrasensitive pheromone detection by mammalian vomeronasal neurons". Nature. 405 (6788): 792–796. Bibcode:2000Natur.405..792L. doi:10.1038/35015572. ISSN 0028-0836. PMID 10866200.
  • Leypold, Bradley G.; Yu, C. Ron; Leinders-Zufall, Trese; Kim Michelle M.; Zufall, Frank; Axel, Richard (2002-04-23) Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A. 99 (9):6376-81. PMID 11972034 DOI:10.1073/pnas.082127599
  • Müller, Markus; Niemeyer, Konstantin; Ojha, Navin K.; Porav, Sebastian A.; Vinayagam, Deivanayagabarathy.; Urban, Nicole; Büchau, Fanny; Oleinikov, Katharina; Makke, Mazze; Bauer, Claudia C.; Johnson, Aidan V.; Muench, Stephen P.; Zufall, Frank; Bruns, Dieter; Schwarz, Yvonne; Raunser, Stefan; Leinders-Zufall, Trese; Bon, Robin S.; Schaefer, Michael; Thorn-Seshold, Oliver (2026-01-16) Ideal efficacy photoswitches for chemocontrol of TRPC4/5 channel functions in live tissues. Nature Chem Biol. 22 (2):180-191. PMID 41545580 doi:10.1038/s41589-025-02085-x

References

  1. 1 2 3 4 5 Blum, Thomas; Moreno-Perez; Pyrski; Bufe; Arifovic; Weissgerber; Freichel; Zufall; Leinders-Zufall (2019). "Trpc5 deficieny causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus". Proc Natl Acad Sci USA. 116 (30): 15236–15243. Bibcode:2019PNAS..11615236B. doi:10.1073/pnas.1905705116. PMC 6660783. PMID 31285329.
  2. 1 2 Leinders-Zufall, T.; Lane, A. P.; Puche, A. C.; Ma, W.; Novotny, M. V.; Shipley, M. T.; Zufall, F. (2000-06-15). "Ultrasensitive pheromone detection by mammalian vomeronasal neurons". Nature. 405 (6788): 792–796. Bibcode:2000Natur.405..792L. doi:10.1038/35015572. ISSN 0028-0836. PMID 10866200.
  3. 1 2 Perniss, Alexander; Boonen, Brett; Tonack, Sarah; Thiel, Moritz; Poharkar, Krupali; Alnouri, Mohamad Wessam; Keshavarz, Maryam; Papadakis, Tamara; Wiegand, Silke; Pfeil, Uwe; Richter, Katrin; Althaus, Mike; Oberwinkler, Johannes; Schütz, Burkhard; Boehm, Ulrich (2023-08-02). "A succinate/SUCNR1-brush cell defense program in the tracheal epithelium". Science Advances. 9 (31) eadg8842. Bibcode:2023SciA....9G8842P. doi:10.1126/sciadv.adg8842. ISSN 2375-2548. PMC 10396310. PMID 37531421.
  4. ↑ "idw: "Immer der Nase nach": Erste W3-Lichtenberg-Professur im Saarland" (in German). 2007-07-18.
  5. 1 2 Leinders-Zufall, Trese; Ishii, Tomohiro; Chamero, Pablo; Hendrix, Philipp; Oboti, Livio; Schmid, Andreas; Kircher, Sarah; Pyrski, Martina; Akiyoshi, Sachiko; Khan, Mona; Vaes, Evelien; Zufall, Frank; Mombaerts, Peter (2014-04-09). "A Family of Nonclassical Class I MHC Genes Contributes to Ultrasensitive Chemodetection by Mouse Vomeronasal Sensory Neurons". Journal of Neuroscience. 34 (15): 5121–5133. doi:10.1523/JNEUROSCI.0186-14.2014. ISSN 0270-6474. PMC 4050176. PMID 24719092.
  6. 1 2 Koike, Kohei; Teuchert; Schmid; Pyrski; Perez-Gomez; Eisenbein; Timm; Ishii; Lochnit; Bischoff; Mombaerts; Leinders-Zufall; Zufall (2021). "Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide". Neuron. 109 (15): 2469–2484.e7. doi:10.1016/j.neuron.2021.05.032. PMID 34186026.
  7. ↑ Pérez-Gómez, Anabel; Bleymehl, Katherin; Stein, Benjamin; Pyrski, Martina; Birnbaumer, Lutz; Munger, Steven D.; Leinders-Zufall, Trese; Zufall, Frank; Chamero, Pablo (2015-05-18). "Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial Hypothalamus". Current Biology. 25 (10): 1340–1346. Bibcode:2015CBio...25.1340P. doi:10.1016/j.cub.2015.03.026. ISSN 1879-0445. PMC 4439360. PMID 25936549.
  8. 1 2 Lucas, Philippe; Ukhanov, Kyrill; Leinders-Zufall, Trese; Zufall, Frank (2003-10-30). "A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction". Neuron. 40 (3): 551–561. doi:10.1016/s0896-6273(03)00675-5. ISSN 0896-6273. PMID 14642279.
  9. ↑ Leinders-Zufall, Trese; Rand, Mark N.; Shepherd, Gordon M.; Greer, Charles A.; Zufall, Frank (1997-06-01). "Calcium Entry through Cyclic Nucleotide-Gated Channels in Individual Cilia of Olfactory Receptor Cells: Spatiotemporal Dynamics". Journal of Neuroscience. 17 (11): 4136–4148. doi:10.1523/JNEUROSCI.17-11-04136.1997. ISSN 0270-6474. PMC 6573532. PMID 9151731.
  10. 1 2 3 Leinders, Trese; van Kleef; Vijverberg (1992). "Single Ca(2+)-activated K+ channels in human erythrocytes: Ca2+ dependence of opening frequency but not of open lifetimes". Biochim Biophys Acta. 1112 (1): 67–74. doi:10.1016/0005-2736(92)90255-k. PMID 1420271.
  11. 1 2 Chamero, Pablo; Katsoulidou, Vicky; Hendrix, Philipp; Bufe, Bernd; Roberts, Richard; Matsunami, Hiroaki; Abramowitz, Joel; Birnbaumer, Lutz; Zufall, Frank; Leinders-Zufall, Trese (2011-08-02). "G protein Gαo is essential for vomeronasal function and aggressive behavior in mice". Proceedings of the National Academy of Sciences. 108 (31): 12898–12903. doi:10.1073/pnas.1107770108. ISSN 0027-8424. PMC 3150917. PMID 21768373.
  12. ↑ Trouillet, Anne-Charlotte; Keller, Matthieu; Weiss, Jan; Leinders-Zufall, Trese; Birnbaumer, Lutz; Zufall, Frank; Chamero, Pablo (2019-03-12). "Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice". Proceedings of the National Academy of Sciences. 116 (11): 5135–5143. doi:10.1073/pnas.1821492116. ISSN 0027-8424. PMC 6421405. PMID 30804203.
  13. 1 2 Ojha, Navin K.; Zufall, Frank; Leinders-Zufall, Trese (2023). "Optical Activation of Photoswitchable TRPC Ligands in the Mammalian Olfactory System Using Laser Scanning Confocal Microscopy". The Olfactory System. Methods in Molecular Biology (Clifton, N.J.). Vol. 2710. pp. 31–47. doi:10.1007/978-1-0716-3425-7_3. ISBN 978-1-0716-3424-0. ISSN 1940-6029. PMID 37688722.
  14. 1 2 Leinders-Zufall, T.; Shepherd, G. M.; Zufall, F. (1995-10-01). "Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide". Journal of Neurophysiology. 74 (4): 1498–1508. doi:10.1152/jn.1995.74.4.1498. ISSN 0022-3077.
  15. ↑ Zufall, F; Firestein, S; Shepherd, Gm (1991-11-01). "Analysis of single cyclic nucleotide-gated channels in olfactory receptor cells". The Journal of Neuroscience. 11 (11): 3573–3580. doi:10.1523/JNEUROSCI.11-11-03573.1991. ISSN 0270-6474.
  16. ↑ Shepherd, Gordon M. (2012). Squire, Larry R. (ed.). Gordon Shepherd (PDF) (7 ed.). New York: Society of Neuroscience. pp. 642–703. ISBN 0-19-539613-8.
  17. ↑ Leinders-Zufall, Trese; Rand, Mark N.; Shepherd, Gordon M.; Greer, Charles A.; Zufall, Frank (1997-06-01). "Calcium Entry through Cyclic Nucleotide-Gated Channels in Individual Cilia of Olfactory Receptor Cells: Spatiotemporal Dynamics". The Journal of Neuroscience. 17 (11): 4136–4148. doi:10.1523/JNEUROSCI.17-11-04136.1997. ISSN 0270-6474.
  18. ↑ Leinders-Zufall, Trese; Greer, Charles A.; Shepherd, Gordon M.; Zufall, Frank (1998-08-01). "Imaging Odor-Induced Calcium Transients in Single Olfactory Cilia: Specificity of Activation and Role in Transduction". The Journal of Neuroscience. 18 (15): 5630–5639. doi:10.1523/JNEUROSCI.18-15-05630.1998. ISSN 0270-6474. PMC 6793047.
  19. ↑ Leinders-Zufall, Trese; Lane, Andrew P.; Puche, Adam C.; Ma, Weidong; Novotny, Milos V.; Shipley, Michael T.; Zufall, Frank (2000-06-15). "Ultrasensitive pheromone detection by mammalian vomeronasal neurons". Nature. 405 (6788): 792–796. doi:10.1038/35015572. ISSN 1476-4687.
  20. ↑ Chen, Wen G.; Schloesser, Dana; Arensdorf, Angela M.; Simmons, Janine M.; Cui, Changhai; Valentino, Rita; Gnadt, James W.; Nielsen, Lisbeth; Hillaire-Clarke, Coryse St; Spruance, Victoria; Horowitz, Todd S.; Vallejo, Yolanda F.; Langevin, Helene M. (2021-01-01). "The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self". Trends in Neurosciences. 44 (1): 3–16. doi:10.1016/j.tins.2020.10.007. ISSN 1878-108X. PMC 7780231. PMID 33378655.
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