Trehalose-phosphatase

trehalose-phosphatase
Identifiers
EC no.3.1.3.12
CAS no.9025-72-3
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme trehalose-phosphatase (EC 3.1.3.12) catalyzes the reversible reaction

2D representation of the chemical structure of Q27102967.
α,α-trehalose 6-phosphate
 
H2O
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
H2O
Pi
 
2D representation of the chemical structure of trehalose .
trehalose

The enzyme characterised from locust hydrolyses α,α-trehalose 6-phosphate to trehalose and orthophosphate.[1][2] The enzyme is present in many organisms including plants, fungi and animals.[3][4]

This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is α,α-trehalose-6-phosphate phosphohydrolase. Other names in common use include trehalose 6-phosphatase, trehalose 6-phosphate phosphatase, and trehalose-6-phosphate phosphohydrolase.[5]

References

  1. ↑ Cabib E, Leloir LF (1958). "The biosynthesis of trehalose phosphate". J. Biol. Chem. 231 (1): 259–75. doi:10.1016/S0021-9258(19)77303-7. hdl:11336/135983. PMID 13538966.
  2. ↑ Candy DJ, Kilby BA (1961). "The biosynthesis of trehalose in the locust fat body". Biochem. J. 78 (3): 531–6. doi:10.1042/bj0780531. PMC 1205371. PMID 13690400.
  3. ↑ Avonce, Nelson; Mendoza-Vargas, Alfredo; Morett, Enrique; Iturriaga, Gabriel (2006). "Insights on the evolution of trehalose biosynthesis". BMC Evolutionary Biology. 6 109. doi:10.1186/1471-2148-6-109. PMC 1769515. PMID 17178000.
  4. ↑ De Oliveira, Lauana Pereira; Navarro, Bruno Viana; De Jesus Pereira, João Pedro; Lopes, Adriana Rios; Martins, Marina C. M.; Riaño-Pachón, Diego Mauricio; Buckeridge, Marcos Silveira (2022). "Bioinformatic analyses to uncover genes involved in trehalose metabolism in the polyploid sugarcane". Scientific Reports. 12 (1) 7516. doi:10.1038/s41598-022-11508-x. PMC 9079074. PMID 35525890.
  5. ↑ Enzyme 3.1.3.12 at KEGG Pathway Database.
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