Tocopherol O-methyltransferase
| Tocopherol O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.95 | ||||||||
| CAS no. | 84788-82-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tocopherol O-methyltransferase (EC 2.1.1.95) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which one of the vitamin E components, γ-tocopherol, is converted to the more commonly found α-tocopherol.[1] The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).[2]
The enzymes from Arabidopsis thaliana and Capsicum annuum can also convert δ-tocopherol into β-tocopherol and are effective on tocotrienols, by addition of a methyl group at the same relative position as in γ-tocopherol.[3][4]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase. This enzyme is also called gamma-tocopherol methyltransferase.[5]
References
- ↑ Burton, G. W.; Ingold, K. U. (1 June 1986). "Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function". Accounts of Chemical Research. 19 (7): 194–201. doi:10.1021/ar00127a001.
- ↑ Camara, Bilal; d'Harlingue, Alain (1985). "Demonstration and solubilization of S-adenosylmethionine: γ-tocopherol methyltransferase from Capsicum chromoplasts". Plant Cell Reports. 4 (1): 31–32. doi:10.1007/BF00285499. PMID 24253640.
- ↑ Koch, Maria; Lemke, Rainer; Heise, Klaus-Peter; Mock, Hans-Peter (2003). "Characterization of γ-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana". European Journal of Biochemistry. 270 (1): 84–92. doi:10.1046/j.1432-1033.2003.03364.x. PMID 12492478.
- ↑ Zhang, Gui-Yun; Liu, Ru-Ru; Xu, Geng; Zhang, Peng; Li, Yin; Tang, Ke-Xuan; Liang, Guo-Hua; Liu, Qiao-Quan (2013). "Increased α-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis γ-tocopherol methyltransferase". Transgenic Research. 22 (1): 89–99. doi:10.1007/s11248-012-9630-2. PMID 22763462.
- ↑ Enzyme 2.1.1.95 at KEGG Pathway Database.
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