Thyroid-hormone transaminase
| Thyroid-hormone transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.26 | ||||||||
| CAS no. | 51004-29-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thyroid-hormone transaminase (EC 2.6.1.26) is an enzyme that catalyzes the chemical reaction
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The two substrates of this enzyme characterised from rabbit kidney and liver are the thyroid hormone, triiodothyronine, and α-ketoglutaric acid. Its products are 3,5,3'-triiodothyropyruvic acid and L-glutamic acid.[1]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase. Other names in common use include 3,5-dinitrotyrosine transaminase, and thyroid hormone aminotransferase. It uses pyridoxal phosphate as a cofactor.[2]
References
- ↑ Soffer RL, Hechtman P, Savage M (1973). "L-Triiodothyronine aminotransferase". J. Biol. Chem. 248 (4): 1224–30. doi:10.1016/S0021-9258(19)44286-5. PMID 4686924.
- ↑ Enzyme 2.6.1.26 at KEGG Pathway Database.