Thymidylate 5'-phosphatase
| thymidylate 5′-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.35 | ||||||||
| CAS no. | 9026-80-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme thymidylate 5′-phosphatase (EC 3.1.3.35) catalyzes the reaction
The enzyme characterised from Bacillus subtilis hydrolyses thymidine monophosphate to thymidine and orthophosphate.[1][2] Thermodynamic properties for the reaction have been calculated.[3]
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is thymidylate 5′-phosphohydrolase. Other names in use include thymidylate 5′-nucleotidase, deoxythymidylate 5′-nucleotidase, thymidylate nucleotidase, deoxythymidylic 5′-nucleotidase, deoxythymidylate phosphohydrolase, and dTMPase.[4]
References
- ↑ Aposhian HV, Tremblay GY (1966). "Deoxythymidylate 5′-nucleotidase. Purification and properties of an enzyme found after infection of Bacillus subtilis with phage SP5C". J. Biol. Chem. 241 (21): 5095–101. doi:10.1016/S0021-9258(18)99675-4. PMID 4958986.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "Thymidylate 5'-phosphatase". Enzyme Handbook 3. pp. 455–458. doi:10.1007/978-3-642-76463-9_96. ISBN 978-3-642-48962-4.
- ↑ Alberty, Robert A. (2007). "Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides". Biophysical Chemistry. 127 (1–2): 91–96. doi:10.1016/j.bpc.2006.12.010. PMC 1987330. PMID 17240519.
- ↑ Enzyme 3.1.3.35 at KEGG Pathway Database.
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