TTI2

TTI2
Identifiers
Aliases	TTI2, C8orf41, MRT39, TELO2 interacting protein 2
External IDs	OMIM: 614426; MGI: 2384576; GeneCards: TTI2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	33,513,185 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	31,654,730 bp
RNA expression pattern
	Top expressed in
	testicle; ; ventricular zone; ; gonad; ; islet of Langerhans; ; ganglionic eminence; ; mucosa of transverse colon; ; stromal cell of endometrium; ; gastrocnemius muscle; ; right testis; ; left testis;
	Top expressed in
	otic vesicle; ; otic placode; ; primitive streak; ; saccule; ; submandibular gland; ; lumbar subsegment of spinal cord; ; tail of embryo; ; gastrula; ; granulocyte; ; ventricular zone;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	80185
	234138
	ENSG00000129696
	ENSMUSG00000031577
	Q6NXR4
	Q8BGV4
	NM_001102401; NM_001265581; NM_025115; NM_001330505
	NM_001112729; NM_001199988; NM_144927
	NP_001095871; NP_001252510; NP_001317434; NP_079391
	NP_001186917; NP_659176
	Wikidata
View/Edit Human	View/Edit Mouse

TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans.^[5]

Function

This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.

The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129696 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031577 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.

Function

References

Further reading