GFUS

GFUS
Identifiers
Aliases	GFUS, FX, P35B, SDR4E1, tissue specific transplantation antigen P35B, TSTA3, GDP-L-fucose synthase
External IDs	OMIM: 137020; MGI: 98857; GeneCards: GFUS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B8W, 4BKP, 4E5Y, 4B8Z, 4BL5
Enzyme activity
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,618,048 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	75,801,681 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; skin of abdomen; ; mucosa of esophagus; ; duodenum; ; skin of leg; ; salivary gland; ; minor salivary glands; ; body of pancreas; ; mucosa of transverse colon; ; fundus;
	Top expressed in
	Paneth cell; ; crypt of lieberkuhn of small intestine; ; pyloric antrum; ; large intestine; ; colon; ; lacrimal gland; ; motor neuron; ; duodenum; ; seminal vesicula; ; facial motor nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; GDP-4-dehydro-D-rhamnose reductase activity; catalytic activity; oxidoreductase activity; GDP-L-fucose synthase activity; isomerase activity; identical protein binding; GDP-mannose 3,5-epimerase activity;
Cellular component	extracellular exosome; cytosol; cytoplasm;
Biological process	GDP-mannose metabolic process; leukocyte cell-cell adhesion; metabolism; cytolysis; 'de novo' GDP-L-fucose biosynthetic process; nucleotide-sugar biosynthetic process; electron transport chain; T cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7264
	22122
	ENSG00000104522; ENSG00000278243
	ENSMUSG00000022570
	Q13630
	P23591
	NM_003313; NM_001317783
	NM_031201; NM_001357005
	NP_001304712; NP_003304
	NP_112478; NP_001343934
	Wikidata
View/Edit Human	View/Edit Mouse

GDP-L-fucose synthase is an enzyme that in humans is encoded by the GFUS gene (previously TSTA3).^[5]^[6]^[7]^[8]

As its name suggests, the GFUS protein functions as a GDP-L-fucose synthase. As part of this, it binds to NADP(H). It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.^[8]

References

1 2 3 ENSG00000278243 GRCh38: Ensembl release 89: ENSG00000104522, ENSG00000278243 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022570 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood. 85 (1): 264–7. doi:10.1182/blood.V85.1.264.bloodjournal851264. PMID 7803801.
↑ Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics. 35 (5): 316–23. doi:10.1007/bf00189894. PMID 1348494. S2CID 9048773.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
1 2 "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human GDP-L-fucose synthase

[refGRCh38Ensembl-1] 1 2 3 ENSG00000278243 GRCh38: Ensembl release 89: ENSG00000104522, ENSG00000278243 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022570 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7803801-5] Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood. 85 (1): 264–7. doi:10.1182/blood.V85.1.264.bloodjournal851264. PMID 7803801.

[pmid1348494-6] Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics. 35 (5): 316–23. doi:10.1007/bf00189894. PMID 1348494. S2CID 9048773.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] 1 2 "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

References

Further reading

External links