Translocated promoter region

TPR
Identifiers
Aliases	TPR, translocated promoter region, nuclear basket protein
External IDs	OMIM: 189940; MGI: 1922066; GeneCards: TPR
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.1 Start 186,311,652 bp End 186,375,693 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 G1 Start 150,268,589 bp End 150,325,686 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii optic nerve pylorus Achilles tendon lactiferous duct superficial temporal artery renal medulla ventricular zone pericardium internal globus pallidus Top expressed in genital tubercle tail of embryo ventricular zone Rostral migratory stream otic placode saccule neural layer of retina epiblast yolk sac Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity tubulin binding structural constituent of nuclear pore heat shock protein binding mRNA binding protein homodimerization activity chromatin binding protein binding dynein complex binding protein-membrane adaptor activity mitogen-activated protein kinase binding RNA binding Cellular component cytoplasm nuclear membrane nuclear envelope nuclear periphery membrane cytoskeleton nucleus kinetochore nuclear inclusion body chromosome, centromeric region spindle nucleoplasm chromosome mitotic spindle extrinsic component of membrane nuclear pore cytoplasmic dynein complex nuclear pore nuclear basket host cell Biological process positive regulation of mitotic cell cycle spindle assembly checkpoint nuclear pore complex assembly protein import into nucleus RNA export from nucleus cell cycle mRNA transport regulation of protein stability regulation of protein export from nucleus viral transcription RNA import into nucleus protein sumoylation positive regulation of protein export from nucleus mitotic nuclear membrane disassembly protein export from nucleus regulation of protein import into nucleus protein transport positive regulation of protein import into nucleus viral process negative regulation of RNA export from nucleus nuclear pore organization mRNA export from nucleus in response to heat stress positive regulation of intracellular protein transport negative regulation of transcription by RNA polymerase II regulation of mitotic sister chromatid separation mitotic spindle assembly checkpoint signaling response to epidermal growth factor cellular response to interferon-alpha negative regulation of translational initiation regulation of mRNA export from nucleus positive regulation of heterochromatin assembly regulation of mitotic spindle assembly cell division regulation of cellular response to heat nuclear matrix organization intracellular transport of virus mRNA export from nucleus tRNA export from nucleus cellular response to heat regulation of gene silencing by miRNA regulation of glycolytic process transport regulation of protein localization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7175 108989 Ensembl ENSG00000047410 ENSMUSG00000006005 UniProt P12270 Q5SWX9 F6ZDS4 RefSeq (mRNA) NM_003292 NM_133780 RefSeq (protein) NP_003283 NP_598541 Location (UCSC) Chr 1: 186.31 – 186.38 Mb Chr 1: 150.27 – 150.33 Mb PubMed search
Wikidata
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translocated promoter region (to activated MET oncogene)
Identifiers
Symbol	TPR
NCBI gene	7175
HGNC	12017
OMIM	189940
RefSeq	NM_003292
UniProt	P12270
Other data
Locus	Chr. 1 q25
Search for Structures Swiss-model Domains InterPro

Translocated promoter region is a component of the tpr-met fusion protein.

External links

• TPR+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)