Transmembrane protein 175

TMEM175
Identifiers
Aliases	TMEM175, htransmembrane protein 175
External IDs	OMIM: 616660; MGI: 1919642; GeneCards: TMEM175
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 932,387 bp End 958,656 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 108,777,636 bp End 108,796,648 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte anterior pituitary right frontal lobe apex of heart C1 segment Brodmann area 9 spleen right lobe of thyroid gland right lobe of liver Top expressed in spermatocyte spermatid right kidney seminiferous tubule superior frontal gyrus zygote secondary oocyte primary visual cortex proximal tubule lumbar spinal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function potassium ion leak channel activity potassium channel activity Cellular component integral component of membrane lysosomal membrane endosome lysosome endosome membrane membrane Biological process potassium ion transport regulation of lysosomal lumen pH phagosome-lysosome fusion ion transport potassium ion transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 84286 72392 Ensembl ENSG00000127419 ENSMUSG00000013495 UniProt Q9BSA9 Q9CXY1 RefSeq (mRNA) NM_001297423 NM_001297424 NM_001297425 NM_001297426 NM_001297427 NM_001297428 NM_032326 NM_001163531 NM_001163532 NM_028223 NM_001359423 NM_001359426 NM_001359427 RefSeq (protein) NP_001284352 NP_001284353 NP_001284354 NP_001284355 NP_001284356 NP_001284357 NP_115702 NP_001157003 NP_001157004 NP_082499 NP_001346352 NP_001346355 NP_001346356 Location (UCSC) Chr 4: 0.93 – 0.96 Mb Chr 5: 108.78 – 108.8 Mb PubMed search
Wikidata
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Transmembrane protein 175
Identifiers
Symbol	TMEM175
Pfam	PF06736
InterPro	IPR010617
TCDB	1.A.78
OPM superfamily	467
OPM protein	5vre
Available protein structures: PDB   IPR010617 PF06736 (ECOD; PDBsum)   AlphaFold IPR010617 PF06736

Transmembrane protein 175
Identifiers
Symbol	TMEM175
Alt. symbols	MGC4618
NCBI gene	84286
HGNC	28709
RefSeq	NM_032326
UniProt	Q9BSA9
Other data
Locus	Chr. 4 p16.3
Search for Structures Swiss-model Domains InterPro

Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

Expression

Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level (75-98%) in normal tissues. TMEM175 appears to be down regulated in stage three ovarian cancer.

Homology

Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLAST and BLAT. This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.

Scientific name	Common name	Accession number	Sequence length	Percent identity	Percent Similarity
Homo Sapiens	Human	NP_115702.1	504	-	-
Pan troglodytes	Chimp	XP_001141076	504	92	93
Pongo abelii	Orangutan	XP_002814537	231	99	99
Macaca mulatta	Rhesus	XP_001085173.1	403	96	98
Callithrix jacchus	Marmoset	XP_002746113.1	472	83	87
Bos taurus	Cow	NP_001069081.1	479	77	82
Ailuropoda melanoleuca	Panda	XP_002924455.1	498	81	87
Equus caballus	Horse	XP_001488271.1	499	81	86
Rattus norvegicus	Rat	NP_001014013.1	499	82	88
Mus musculus	Mouse	NP_082499.3	499	81	88
Monodelphis domestica	Opossum	XP_001377424.1	502	67	80
Ornithorhynchus anatinus	Platypus	XP_001514176	499	68	82
Gallus gallus	Chicken	NP_001006582.1	501	64	78
Sceloporus occidentalis	Lizard	-	417	56	66
Taeniopygia guttata	Zebra Finch	XP_002187908.1	496	66	79
Danio rerio	Zebra Fish	NP_001093545.1	520	62	76
Branchiostoma floridae	Lancelet	XP_002596272	409	31	50
Ciona intestinalis	Sea Squirt	XP_002122718	494	27	50
Nematostella vectensis	Starlet Sea Anemone	XP_001630719	489	28	49

Predicted Post-Translational Modification

Using various tools at ExPASy the following are possible post-translational modifications for TMEM175.

• 5 possible CK2 phosphorylation sites
• 2 possible PKC phosphorylation sites
• N-myristoylation sites around transmembrane regions

The N-myristoylation sites are conserved in vertebrates.

Further reading

• "Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases". National Institutes of Health (NIH). 2021-02-16. Retrieved 2023-08-07.