Syndetin

VPS50
Identifiers
Aliases	VPS50, CCDC132, VPS54L, FLJ20097 / CCDC132, EARP/GARPII complex subunit, VPS50 subunit of EARP/GARPII complex, NEDMSC
External IDs	OMIM: 616465; MGI: 1920538; GeneCards: VPS50
Gene location (Human)
Chr.	Chromosome 7 (human)
End	93,361,123 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	3,603,531 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; tibialis anterior muscle; ; Brodmann area 46; ; middle temporal gyrus; ; Brodmann area 23; ; secondary oocyte; ; superior frontal gyrus; ; postcentral gyrus; ; sperm;
	Top expressed in
	genital tubercle; ; superior cervical ganglion; ; spermatid; ; zygote; ; tail of embryo; ; secondary oocyte; ; dentate gyrus of hippocampal formation granule cell; ; primary motor cortex; ; visual cortex; ; habenula;
	More reference expression data
	n/a
Gene ontology
Molecular function	SNARE binding; protein binding;
Cellular component	recycling endosome; EARP complex; endosome; extracellular exosome; membrane; cytosol;
Biological process	protein transport; retrograde transport, endosome to Golgi; endocytic recycling; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55610
	73288
	ENSG00000004766
	ENSMUSG00000001376
	Q96JG6
	Q8CI71
	NM_001257998; NM_017667; NM_024553
	NM_001167750; NM_001167751; NM_024260
	NP_001244927; NP_060137; NP_078829
	NP_001161222; NP_001161223; NP_077222
	Wikidata
View/Edit Human	View/Edit Mouse

Syndetin is a protein that in humans is encoded by the VPS50 gene. It is a component of the EARP complex that is involved in endocytic recycling.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000004766 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001376 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schindler C, Chen Y, Pu J, Guo X, Bonifacino JS (2015). "EARP is a multisubunit tethering complex involved in endocytic recycling". Nature Cell Biology. 17 (5): 639–50. doi:10.1038/ncb3129. PMC 4417048. PMID 25799061.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000004766 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001376 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid25799061-5] Schindler C, Chen Y, Pu J, Guo X, Bonifacino JS (2015). "EARP is a multisubunit tethering complex involved in endocytic recycling". Nature Cell Biology. 17 (5): 639–50. doi:10.1038/ncb3129. PMC 4417048. PMID 25799061.

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