Sylvia Daunert

Sylvia Daunert
FRSC
EducationUniversity of Barcelona (PharmD, PhD); University of Michigan (MS)
AwardsNational Science Foundation CAREER Award; Fellow of the Royal Society of Chemistry; Fellow of the National Academy of Inventors
Scientific career
FieldsBioanalytical chemistry; biosensors; nanotechnology
WorkplacesUniversity of Miami Miller School of Medicine; University of Kentucky

Sylvia Daunert is a Spanish-American bioanalytical chemist and academic known for her work in biosensors, bioanalytical chemistry, and biomedical nanotechnology. She is a professor and the Lucille P. Markey Chair in the Department of Biochemistry and Molecular biology at the University of Miami Miller School of Medicine. Daunert has been elected a Fellow of the Royal Society of Chemistry and the National Academy of Inventors.

Education

Daunert earned a PharmD from the University of Barcelona in 1982. She received a Master of Science in medicinal chemistry from the University of Michigan in 1985, followed by a PhD in bioanalytical chemistry from the University of Barcelona in 1991.[1][2]

Career

Daunert held faculty appointments at the University of Kentucky from 1994 to 2010, serving in the departments of chemistry and pharmaceutical sciences. She was later Gill Eminent Professor of Biological and Analytical Chemistry.[3][4][1]

In 2010, she joined the University of Miami Miller School of Medicine as professor and Lucille P. Markey Chair in the Department of Biochemistry and Molecular Biology.[5] She has held several leadership roles at the University of Miami, including Director of the Dr. JT Macdonald Foundation Biomedical Nanotechnology Institute,[6] Director of Frost Institutes and University STEM Centers and Institutes,[7] and Interim Director of the Frost Institute for Chemistry and Molecular Sciences.[8]

Research

Daunert's research is in bioanalytical chemistry, bionanotechnology, biosensor development, molecular diagnostics, and drug delivery, with applications in biomedical and environmental monitoring.[9][10] A recurring theme in her work has been the use of genetically engineered proteins and living cells as analytical sensing systems. In 2000, Daunert and colleagues reviewed the use of genetically engineered whole-cell sensing systems that couple biological recognition with reporter genes.[11] Related studies have examined bacterial biosensors for arsenite and arsenate in drinking water and whole-cell systems for detecting quorum sensing molecules such as autoinducer-2.[12][13]

Her work has also addressed stimuli-responsive biomaterials and nanotechnology-based drug delivery. A 2005 study in Nature Materials reported the use of genetically engineered proteins to alter the responsive properties of hydrogels.[14] Later collaborative work reviewed nanotechnology-based approaches to drug delivery and investigated nanodrug formulations for neurological and infectious-disease applications, including opioid antagonist nanodrugs for ischemic stroke and therapeutic nanoparticles for Zika virus.[15][16][17]

Daunert's group and collaborators have developed point-of-care and paper-based diagnostic systems. These include a paper-strip and smartphone-based test for bacterial vaginosis and an isothermal point-of-care test for screening for SARS-CoV-2.[18][19] During the COVID-19 pandemic, Florida Trend reported that University of Miami biomedical researchers led by Daunert were developing a point-of-care coronavirus test in collaboration with Heat Biologics.[20]

Another area of her research concerns environmental and occupational exposure monitoring. In work associated with the Firefighter Cancer Initiative, Daunert and collaborators evaluated silicone wristbands as passive sampling systems for measuring polycyclic aromatic hydrocarbon exposure among firefighters.[21] Her collaborative work on microbial signaling has also included studies of quorum-sensing molecules in disease-related contexts, including Crohn's disease and microbiome-associated depressive-like behavior in mice.[22][23]

Awards and honors

References

  1. 1 2 Roda, Aldo (2016). "In honor of Professor Sylvia Daunert". Analytical and Bioanalytical Chemistry. 408: 7883–7884. doi:10.1007/s00216-016-9770-y.
  2. ↑ Salins, Lyndon L. E.; Deo, Sapna K.; Daunert, Sylvia (2004). "Phosphate binding protein as the biorecognition element in a biosensor for phosphate". Sensors and Actuators B: Chemical. 97 (1): 81–89. doi:10.1016/j.snb.2003.07.019.
  3. ↑ "Bioanalytical Brilliance". Miami.edu.
  4. ↑ "Glowing Bacteria Light the Way to Clean Water". UKNow. University of Kentucky. 26 January 2010.
  5. ↑ "Message from the Chair". Miami.edu.
  6. ↑ Bell, Maya (18 October 2018). "Dr. Sylvia Daunert Aims for Huge Breakthroughs on the Nanoscale". Miller School of Medicine - University of Miami.
  7. ↑ "University Level STEM Centers and Institutes | Provost Office | University of Miami". Miami.edu.
  8. ↑ "Sylvia Daunert PharmD MS PhD". med.miami.edu.
  9. ↑ "Sylvia Daunert". Academy of Sciences, Engineering and Medicine of Florida.
  10. ↑ "Dr. Sylvia Daunert Aims for Huge Breakthroughs on the Nanoscale". InventUM. University of Miami Miller School of Medicine. 18 October 2018.
  11. ↑ Daunert, S.; Barrett, G.; Feliciano, J. S.; Shetty, R. S.; Shrestha, S.; Smith-Spencer, W. (2000). "Genetically engineered whole-cell sensing systems: coupling biological recognition with reporter genes". Chemical Reviews. 100 (7): 2705–2738. doi:10.1021/cr990115p.
  12. ↑ Stocker, Judith; Balluch, Denisa; Gsell, Monika; Harms, Hauke; Feliciano, Jessika; Daunert, Sylvia; Malik, Khurseed A.; van der Meer, Jan Roelof (2003). "Development of a set of simple bacterial biosensors for quantitative and rapid measurements of arsenite and arsenate in potable water". Environmental Science & Technology. 37 (20): 4743–4750. doi:10.1021/es034258b. PMID 14594387.
  13. ↑ Raut, Neha; Pasini, Paolo; Daunert, Sylvia (2013). "Deciphering bacterial universal language by detecting the quorum sensing signal, autoinducer-2, with a whole-cell sensing system". Analytical Chemistry. 85 (20): 9604–9609. doi:10.1021/ac401776k. PMID 24047052.
  14. ↑ Ehrick, Jonathan D.; Deo, Sapna K.; Browning, Todd W.; Bachas, Leonidas G.; Madou, Marc J.; Daunert, Sylvia (2005). "Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics". Nature Materials. 4 (4): 298–302. doi:10.1038/nmat1352. PMID 15765106.
  15. ↑ Deo, Sapna K.; Dhar, Shanta; Daunert, Sylvia (2022). "Drug delivery: Challenges and nanotechnology-based solutions". Molecular Aspects of Medicine. 83 101051. doi:10.1016/j.mam.2021.101051. PMID 34785059.
  16. ↑ Peyravian, Nadia; Sun, Enze; Dikici, Emre; Deo, Sapna; Daunert, Sylvia; Toborek, Michal (2022). "Opioid antagonist nanodrugs successfully attenuate the severity of ischemic stroke". Molecular Pharmaceutics. 19 (7): 2254–2267. doi:10.1021/acs.molpharmaceut.2c00079. PMC 9257743. PMID 35506882.
  17. ↑ Surnar, Bapurao; Kamran, Mohammad Zahid; Shah, Anuj S.; Basu, Uttara; Kolishetti, Nagesh; Deo, Sapna; Jayaweera, Dushyantha T.; Daunert, Sylvia; Dhar, Shanta (2019). "Orally administrable therapeutic synthetic nanoparticle for Zika virus". ACS Nano. 13 (10): 11034–11048. doi:10.1021/acsnano.9b02807. PMC 7053157.
  18. ↑ Pawley, Devon C.; Dikici, Emre; Deo, Sapna K.; Raccamarich, Patricia; Fischl, Margaret A.; Alcaide, Maria; Daunert, Sylvia (2022). "Rapid point-of-care test kit for bacterial vaginosis: detection of vaginolysin and clue cells using paper strips and a smartphone". Analytical Chemistry. 94 (33): 11619–11626. doi:10.1021/acs.analchem.2c02094. PMID 35943181.
  19. ↑ Zingg, Jean-Marc; Yang, Y.-P.; Seely, S.; Joshi, P.; Roshid, M. H.; Iribarren Latasa, F.; O'Connor, G.; Alfaro, J.; Riquelme, E.; Bernales, S.; Dikici, E.; Deo, S.; Daunert, S. (2023). "Rapid isothermal point-of-care test for screening of SARS-CoV-2 (COVID-19)". Aspects of Molecular Medicine. 1 100002. doi:10.1016/j.amolm.2023.100002. PMID 37519861.
  20. ↑ "University of Miami research seeks half-hour coronavirus test". Florida Trend. 26 March 2020.
  21. ↑ Baum, Jeramy L. R.; Killawala, Chitvan; Santiago, Katerina M.; Dikici, Emre; Kobetz, Erin N.; Schaefer Solle, Natasha; Caban-Martinez, Alberto J.; Deo, Sapna K.; Bachas, Leonidas G.; Daunert, Sylvia (2020). "Evaluation of silicone-based wristbands as passive sampling systems using PAHs as an exposure proxy for carcinogen monitoring in firefighters: evidence from the Firefighter Cancer Initiative". Ecotoxicology and Environmental Safety. 205 111100. doi:10.1016/j.ecoenv.2020.111100. PMID 32911453.
  22. ↑ O'Connor, Gregory; Quintero, M. A.; Deo, Sapna K.; Abreu, Maria T.; Daunert, Sylvia (2022). "Bacterial quorum-sensing molecules in serum: a potential tool for Crohn's disease management". Clinical and Translational Gastroenterology. 13 (12) e00547. doi:10.14309/ctg.0000000000000547. PMC 9780115. PMID 36413804.
  23. ↑ Medina-Rodriguez, Eva M.; Madorma, Derik; O'Connor, Gregory; Mason, Brittany L.; Han, Dongmei; Deo, Sapna K.; Oppenheimer, Mark; Nemeroff, Charles B.; Trivedi, Madhukar H.; Daunert, Sylvia; Beurel, Eleonore (2020). "Identification of a signaling mechanism by which the microbiome regulates Th17 cell-mediated depressive-like behaviors in mice". The American Journal of Psychiatry. 177 (10): 974–990. doi:10.1176/appi.ajp.2020.19090960. PMC 7647050. PMID 32731813.
  24. ↑ "Sylvia Daunert Armillas". Red de Becarios de "la Caixa" (in Spanish). Fundación "la Caixa".
  25. ↑ "Cottrell Scholars Dashboard". Research Corporation for Science Advancement.
  26. ↑ "Arthur F. Findeis Award for Achievements by a Young Analytical Scientist". ACS Division of Analytical Chemistry.
  27. ↑ "Faculty Awards | The Graduate School". University of Kentucky.
  28. ↑ "Proceedings of 2016 Kentucky Water Resources Annual Symposium" (PDF). Kentucky Water Resources Research Institute. 2016.
  29. ↑ "Past Winners | Provost's Awards | Provost's Office". University of Miami.
  30. ↑ "141st ADA Annual Meeting Program" (PDF). American Dermatological Association. 2021. p. 7.
  31. ↑ "Memoria 2015" (PDF) (in Spanish). Real Academia Nacional de Farmacia. 2015. p. 8.
  32. ↑ Roda, Aldo (1 November 2016). "In honor of Professor Sylvia Daunert". Analytical and Bioanalytical Chemistry. 408 (28): 7883–7884. doi:10.1007/s00216-016-9770-y. ISSN 1618-2650.
  33. ↑ "I Section - Mathematics, Physics, Chemistry and Geology". Academy of Sciences of Bologna Institute.
  34. ↑ Garcia, Joey (6 May 2024). "Dr. Sylvia Daunert Elected to the U.K. Royal Society of Chemistry". University of Miami.
  35. ↑ "Academy of Science, Engineering and Medicine of Florida Announces New Members and Rising Star Awardees". Academy of Science, Engineering and Medicine of Florida.
  36. ↑ "Announcing the 2025 Global Academy of Nanotechnology Honorees". Florida Association for Nanotechnology. 18 March 2025.
  37. ↑ "CONGRATULATIONS 2025 CLASS OF FELLOWS" (PDF). National Academy of Inventors.
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