Stuart M. Lindsay

Stuart M. Lindsay
Stuart M. Lindsay
Alma materUniversity of Manchester
Known forScanning probr microscopy
Awards
  • Fellow of the American Physical Society (1990)[1]
  • Fellow of the American Association for the Advancement of Science (2003)[1]
  • Fellow of the Institute of Physics (UK) (2011)[1]
  • Fellow of the National Academy of Inventors (2014)[2]
Scientific career
FieldsPhysics, chemistry, biophysics, nanoscience
WorkplacesArizona State University

Stuart M. Lindsay (born 3 July 1951) is a British-American physicist, chemist and biophysicist. He is a Regents' Professor and University Professor of Physics and Chemistry at Arizona State University (ASU), where he directs the Biodesign Institute's Center for Single Molecule Biophysics.[3][4][5]

He is known for his development of scanning probe microscopy (particularly atomic force microscopy).[3][6][7] He co-founded Molecular Imaging Corporation (acquired by Agilent Technologies in 2005, later part of Keysight Technologies), which commercialised advanced liquid-environment scanning probe instruments, and more recently Recognition Analytix.[8][9][10]

Early life and education

Lindsay was born in London, England, and earned his PhD in physics from the University of Manchester in 1976.[1] He then worked briefly in solid-state physics research for Philips Industries in London before moving to the United States.[1]

Career

Lindsay joined the faculty of Arizona State University in 1979 and founded its biophysics program.[1][3] He has held the Edward and Nadine Carson Presidential Chair in Physics and served as director of the Center for Single Molecule Biophysics since its establishment in 2002.[4][2]

In 1993 he co-founded Molecular Imaging Corporation with engineer Tianwei Jing to commercialise liquid-environment atomic force microscopes; the company was acquired by Agilent Technologies in November 2005 and later became part of Keysight Technologies.[8][9][3] He has held consulting roles with Agilent/Keysight and co-founded Recognition Analytix.[3][10]

Research

Lindsay developed the use of scanning tunneling and atomic force microscopy on biomolecules in aqueous environments. This work enabled high-resolution imaging of DNA and nucleoprotein complexes under physiological conditions.[1][3] Early work includes STM/AFM imaging of nucleosome DNA in water (1989).[11]

His group advanced single-molecule electron transport measurements. These include reproducible conductance studies of alkanedithiols and organic molecules.[12][13]

He developed recognition-tunneling methods for identifying individual DNA bases and amino acids at the single-molecule level. He also contributed to nanopore sequencing technologies as co-author of a 2008 Nature Biotechnology review.[7][3]

Lindsay's group has explored long-range electron transport in proteins (protein wires). This includes conductance switching and the role of aromatic residues in mediating conductivity.[14][15]

He holds 56 U.S. patents in scanning probe instrumentation and molecular electronics and has published over 200 peer-reviewed papers.[10][3]

Impact

The instruments developed by Molecular Imaging (now Keysight) have become standard tools in nanotechnology and life-sciences research. The company is cited as a significant economic outcome of federally funded university research.[9] His textbook is used for interdisciplinary nanoscience education.[6] A special issue of the Journal of Physics: Condensed Matter (2012) was dedicated to his work.[1]

Awards and honors

  • Humboldt Senior Scientist Award (1993)[1]
  • Fellow, American Physical Society (1990; for pioneering STM imaging of biomolecules in water)[1]
  • Fellow, American Association for the Advancement of Science (2003)[1]
  • Regents' Professor, Arizona State University (2008)[1]
  • Fellow, Institute of Physics (UK) (2011)[1]
  • Fellow, National Academy of Inventors (2014; inducted 2015)[2]
  • University Professor, Arizona State University (2014)[1]

Selected publications

  • Lindsay, S. M. (2009). Introduction to Nanoscience. Oxford University Press. ISBN 978-0-19-954421-9. (Described as the first comprehensive interdisciplinary textbook on the subject.)[6]
  • Branton, D.; Deamer, D. W.; Marziali, A.; ... Lindsay, S. M. ... (2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology. 26 (10): 1146–1153. doi:10.1038/nbt.1495.[7]
  • Li, X.; He, J.; Hihath, J.; Xu, B.; Lindsay, S. M.; Tao, N. J. (2006). "Conductance of single alkanedithiols...". Journal of the American Chemical Society. 128 (6): 2135–2141. doi:10.1021/ja057316x (662+ citations).[12]
  • Lindsay, S. et al. (1989). "STM and AFM images of nucleosome DNA under water". Journal of Biomolecular Structure & Dynamics. 7 (2): 279–287. doi:10.1080/07391102.1989.10507771 (early pioneering work).[11]
  • Krishnan, S.; Lindsay, S. et al. (2023). "Long-Range Conductivity in Proteins Mediated by Aromatic Residues". ACS Physical Chemistry Au. 3 (5): 362–370. doi:10.1021/acsphyschemau.3c00017.[14]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Tao, Nongjian; Nagahara, Larry; Thundat, Thomas (2012). "Biography of Stuart Lindsay". Journal of Physics: Condensed Matter. 24 (16) 160401. doi:10.1088/0953-8984/24/16/160401.
  2. 1 2 3 "ASU Biodesign's Dr. Stuart Lindsay Named National Academy of Inventors Fellows". AZBio. 22 December 2014. Retrieved 27 February 2026.
  3. 1 2 3 4 5 6 7 8 "Stuart Lindsay". VIB Conferences. Retrieved 27 February 2026.
  4. 1 2 "Stuart Lindsay". Bulletin of the Atomic Scientists. Retrieved 27 February 2026.
  5. ↑ "Stuart Lindsay". Inference Review. Retrieved 27 February 2026.
  6. 1 2 3 "Big book explores a small world: Professor debuts first complete guide to nanoscience". Phys.org. 4 February 2010. Retrieved 27 February 2026.
  7. 1 2 3 Branton, Daniel; Deamer, David W.; Marziali, Andre; et al. (October 2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology. 26 (10): 1146–1153. doi:10.1038/nbt.1495. PMC 2683588. PMID 18846088.
  8. 1 2 "Agilent Technologies Acquires Molecular Imaging and Its Atomic Force Microscopy Technology" (Press release). Agilent Technologies. 29 November 2005. Retrieved 27 February 2026.
  9. 1 2 3 Sparking Economic Growth (PDF) (Report). The Science Coalition. 2010. pp. 11, 143–144. Retrieved 27 February 2026.
  10. 1 2 3 "In the Biodesign Center for Single Molecule Biophysics, the little things add up". ASU News. 3 October 2024. Retrieved 27 February 2026.
  11. 1 2 Lindsay, Stuart; Nagahara, L. A.; Thundat, T.; et al. (1989). "STM and AFM images of nucleosome DNA under water". Journal of Biomolecular Structure & Dynamics. 7 (2): 279–287. doi:10.1080/07391102.1989.10507771.
  12. 1 2 Li, X.; He, J.; Hihath, J.; Xu, B.; Lindsay, S. M.; Tao, N. J. (2006). "Conductance of single alkanedithiols: conduction mechanism and effect of molecule−electrode contacts". Journal of the American Chemical Society. 128 (6): 2135–2141. doi:10.1021/ja057316x. PMID 16464114.
  13. ↑ Salomon, A.; Cahen, D.; Lindsay, S.; et al. (2003). "Comparison of electronic transport measurements on organic molecules". Advanced Materials. 15 (22): 1881–1890. doi:10.1002/adma.200306091.
  14. 1 2 Krishnan, S.; Lindsay, S.; et al. (2023). "Long-Range Conductivity in Proteins Mediated by Aromatic Residues". ACS Physical Chemistry Au. 3 (5): 362–370. doi:10.1021/acsphyschemau.3c00017.
  15. ↑ Zhang, B.; Lindsay, S.; et al. (2019). "Role of contacts in long-range protein conductance". Proceedings of the National Academy of Sciences. 116 (13): 5886–5891. doi:10.1073/pnas.1819674116.
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