Stefano Pileri

Stefano Pileri
OccupationsPathologist and an academic
Academic background
EducationM.D.
Post-doc., Haematopathology
Alma materStudiorum University of Bologna
Kiel University
Academic work
InstitutionsEuropean Institute of Oncology

Stefano Pileri is an Italian pathologist and an academic. He is the Director of the Division of Hemolymphopathological Diagnostics at the European Institute of Oncology.[1]

Pileri's work has focused on haematopathology, especially the classification, diagnosis, and biology of lymphoid and hematopoietic malignancies. He is the recipient of the 2013 “Picchio d’Oro” from the Academy of Medicine of Piceno and was also named Honorary Citizen of Jesi in 2025.[2]

Education

Pileri completed his degree in Medicine from Bologna University in 1976. Later in 1980, he obtained his postdoctoral degree in Haematopathology from Kiel University.[1]

Career

Pileri began his academic career in 1976 as a university assistant at the Institute of Pathologic Anatomy of the University of Bologna. In 1981, he was appointed researcher at the same institution, a position he held until 1986. He then worked as an associate professor from 1986 to 2001, and from 2001 to 2015, he was a full professor of Pathologic Anatomy at the University of Bologna. Additionally, he has held honorary academic appointments throughout his career, including working as the Karl Lennert Lecturer in 2024, the Ferrata Lecturer in 2025, and the Christopher Fletcher Lecturer in 2025.[1]

Pileri has also held administrative appointments throughout his career. He worked as the director of the Complex Unit of Pathological Anatomy from 1995 to 2015. Additionally, he was president of the European Association for Haematopathology between 2006 and 2008.[1] In 2015, he founded the Division of Hemolymphopathological Diagnostics at the European Institute of Oncology and has worked as its Director since its establishment.[3] Moreover, he is also president of the Scientific Board of Diatech Pharmacogenetics.[1]

Research

Pileri's work has centered on the pathology[4] and molecular biology of lymphoid malignancies.[5] He has examined topics related to lymphoma diagnosis[6] and classification,[7] with an emphasis on understanding the biological features of both B-cell[8] and T-cell lymphomas.[9] His studies have examined genetic[10] and immunohistochemical characteristics of specific lymphoma types such as peripheral T-cell lymphomas.[11]

Pileri's research has also extended to methodological aspects of diagnostic pathology[12] and the interpretation of complex disease phenotypes.[4] He has also investigated evolving technologies in molecular pathology to help refine disease categorization[6] and identify potential therapeutic targets in heterogeneous lymphoma subgroups.[13]

Additionally, beyond individual studies of disease entities, Pileri's work has also focused on broader conceptual discussions about lymphoma molecular complexity[14] and classification frameworks in haematopathology.[15]

Awards and honors

Selected articles

  • Stein, H., Foss, H. D., Dürkop, H., Marafioti, T., Delsol, G., Pulford, K., ... & Falini, B. (2000). CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood, The Journal of the American Society of Hematology, 96(12), 3681–3695.
  • Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., ... & Vardiman, J. W. (2008). World Health Organization classification of tumours of haematopoietic and lymphoid tissues.
  • Campo, E., Swerdlow, S. H., Harris, N. L., Pileri, S., Stein, H., & Jaffe, E. S. (2011). The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood, The Journal of the American Society of Hematology, 117(19), 5019–5032.
  • Tiacci, E., Trifonov, V., Schiavoni, G., Holmes, A., Kern, W., Martelli, M. P., ... & Falini, B. (2011). BRAF mutations in hairy-cell leukemia. New England Journal of Medicine, 364(24), 2305–2315.
  • Swerdlow, S. H., Campo, E., Pileri, S. A., Harris, N. L., Stein, H., Siebert, R., ... & Jaffe, E. S. (2016). The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, 127(20), 2375–2390.

References

  1. 1 2 3 4 5 6 7 8 "Curriculum Vitae - Prof. Stefano A. Pileri" (PDF).
  2. 1 2 "Seduta del Consiglio Comunale di Giovedì 26 Febbraio 2026".
  3. ↑ "Stefano Pileri - IEO".
  4. 1 2 Wang, Chun-Meng; Wu, Zhi-Qiang; Wang, Yao; Guo, Ye-Lei; Dai, Han-Ren; Wang, Xiao-Hui; Li, Xiang; Zhang, Ya-Jing; Zhang, Wen-Ying; Chen, Mei-Xia; Zhang, Yan; Feng, Kai-Chao; Liu, Yang; Li, Su-Xia; Yang, Qing-Ming; Han, Wei-Dong (1 March 2017). "Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial". Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. 23 (5): 1156–1166. doi:10.1158/1078-0432.CCR-16-1365. ISSN 1557-3265. PMID 27582488.
  5. ↑ Torres, R.; Martin, M. C.; Garcia, A.; Cigudosa, Juan C.; Ramirez, J. C.; Rodriguez-Perales, S. (3 June 2014). "Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system". Nature Communications. 5 3964. Bibcode:2014NatCo...5.3964T. doi:10.1038/ncomms4964. ISSN 2041-1723. PMID 24888982.
  6. 1 2 de Leval, Laurence; Alizadeh, Ash A.; Bergsagel, P. Leif; Campo, Elias; Davies, Andrew; Dogan, Ahmet; Fitzgibbon, Jude; Horwitz, Steven M.; Melnick, Ari M.; Morice, William G.; Morin, Ryan D.; Nadel, Bertrand; Pileri, Stefano A.; Rosenquist, Richard; Rossi, Davide; Salaverria, Itziar; Steidl, Christian; Treon, Steven P.; Zelenetz, Andrew D.; Advani, Ranjana H.; Allen, Carl E.; Ansell, Stephen M.; Chan, Wing C.; Cook, James R.; Cook, Lucy B.; d'Amore, Francesco; Dirnhofer, Stefan; Dreyling, Martin; Dunleavy, Kieron; Feldman, Andrew L.; Fend, Falko; Gaulard, Philippe; Ghia, Paolo; Gribben, John G.; Hermine, Olivier; Hodson, Daniel J.; Hsi, Eric D.; Inghirami, Giorgio; Jaffe, Elaine S.; Karube, Kennosuke; Kataoka, Keisuke; Klapper, Wolfram; Kim, Won Seog; King, Rebecca L.; Ko, Young H.; LaCasce, Ann S.; Lenz, Georg; Martin-Subero, José I.; Piris, Miguel A.; Pittaluga, Stefania; Pasqualucci, Laura; Quintanilla-Martinez, Leticia; Rodig, Scott J.; Rosenwald, Andreas; Salles, Gilles A.; San-Miguel, Jesus; Savage, Kerry J.; Sehn, Laurie H.; Semenzato, Gianpietro; Staudt, Louis M.; Swerdlow, Steven H.; Tam, Constantine S.; Trotman, Judith; Vose, Julie M.; Weigert, Oliver; Wilson, Wyndham H.; Winter, Jane N.; Wu, Catherine J.; Zinzani, Pier L.; Zucca, Emanuele; Bagg, Adam; Scott, David W. (24 November 2022). "Genomic profiling for clinical decision making in lymphoid neoplasms". Blood. 140 (21): 2195. doi:10.1182/blood.2022015854. ISSN 1528-0020. PMC 9837456. PMID 36001803.
  7. ↑ Susanibar-Adaniya, Sandra; Barta, Stefan K. (1 May 2021). "2021 Update on Diffuse large B cell lymphoma: A review of current data and potential applications on risk stratification and management". American Journal of Hematology. 96 (5): 617–629. doi:10.1002/ajh.26151. ISSN 1096-8652. PMC 8172085. PMID 33661537.
  8. ↑ Scott, David W.; Wright, George W.; Williams, P. Mickey; Lih, Chih-Jian; Walsh, William; Jaffe, Elaine S.; Rosenwald, Andreas; Campo, Elias; Chan, Wing C.; Connors, Joseph M.; Smeland, Erlend B.; Mottok, Anja; Braziel, Rita M.; Ott, German; Delabie, Jan; Tubbs, Raymond R.; Cook, James R.; Weisenburger, Dennis D.; Greiner, Timothy C.; Glinsmann-Gibson, Betty J.; Fu, Kai; Staudt, Louis M.; Gascoyne, Randy D.; Rimsza, Lisa M. (20 February 2014). "Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue". Blood. 123 (8): 1214–1217. doi:10.1182/blood-2013-11-536433. ISSN 1528-0020. PMC 3931191. PMID 24398326.
  9. ↑ Pro, Barbara; Advani, Ranjana; Brice, Pauline; Bartlett, Nancy L.; Rosenblatt, Joseph D.; Illidge, Tim; Matous, Jeffrey; Ramchandren, Radhakrishnan; Fanale, Michelle; Connors, Joseph M.; Fenton, Keenan; Huebner, Dirk; Pinelli, Juan M.; Kennedy, Dana A.; Shustov, Andrei (21 December 2017). "Five-year results of brentuximab vedotin in patients with relapsed or refractory systemic anaplastic large cell lymphoma". Blood. 130 (25): 2709–2717. doi:10.1182/blood-2017-05-780049. ISSN 1528-0020. PMC 5746164. PMID 28974506.
  10. ↑ de Leval, Laurence; Rickman, David S.; Thielen, Caroline; Reynies, Aurélien de; Huang, Yen-Lin; Delsol, Georges; Lamant, Laurence; Leroy, Karen; Brière, Josette; Molina, Thierry; Berger, Françoise; Gisselbrecht, Christian; Xerri, Luc; Gaulard, Philippe (1 June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–4963. doi:10.1182/blood-2006-10-055145. ISSN 0006-4971. PMID 17284527.
  11. ↑ Chen, Kevin H.; Wada, Masayuki; Firor, Amelia E.; Pinz, Kevin G.; Jares, Alexander; Liu, Hua; Salman, Huda; Golightly, Marc; Lan, Fengshuo; Jiang, Xun; Ma, Yupo (30 August 2016). "Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies". Oncotarget. 7 (35): 56220. doi:10.18632/oncotarget.11019. ISSN 1949-2553. PMC 5302909. PMID 27494836.
  12. ↑ Shi, Yuanfei; Xu, Yi; Shen, Huafei; Jin, Jie; Tong, Hongyan; Xie, Wanzhuo (September 2024). "Advances in biology, diagnosis and treatment of DLBCL". Annals of Hematology. 103 (9): 3322. doi:10.1007/s00277-024-05880-z. ISSN 1432-0584. PMC 11358236. PMID 39017945.
  13. ↑ Susanibar-Adaniya, Sandra; Barta, Stefan K. (1 May 2021). "2021 Update on Diffuse large B cell lymphoma: A review of current data and potential applications on risk stratification and management". American Journal of Hematology. 96 (5): 618. doi:10.1002/ajh.26151. ISSN 1096-8652. PMC 8172085. PMID 33661537.
  14. ↑ Kato, Takuya; Wakiyama, Hiroaki; Furusawa, Aki; Choyke, Peter L.; Kobayashi, Hisataka (21 May 2021). "Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy". Cancers. 13 (11): 2535. doi:10.3390/cancers13112535. ISSN 2072-6694. PMC 8196790. PMID 34064074.
  15. ↑ Silkenstedt, Elisabeth; Salles, Gilles; Campo, Elias; Dreyling, Martin (4 May 2024). "B-cell non-Hodgkin lymphomas". Lancet. 403 (10438): 1793. doi:10.1016/S0140-6736(23)02705-8. ISSN 1474-547X. PMC 12261310. PMID 38614113.
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