Sorbitol-6-phosphatase

sorbitol-6-phosphatase
Identifiers
EC no.3.1.3.50
CAS no.80449-21-4
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme sorbitol-6-phosphatase (EC 3.1.3.50) catalyzes the reaction

2D representation of the chemical structure of Q27102187.
sorbitol 6-phosphate
 
H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of sorbitol .
sorbitol

The enzyme characterised from apple seedlings hydrolyses sorbitol 6-phosphate to sorbitol and orthophosphate.[1][2] The enzyme is a regulator of energy metabolism in silkworm.[3] It has been studied as a means of producing sorbitol by photosynthesis in engineered cyanobacteria.[4]

This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name of this enzyme class is sorbitol-6-phosphate phosphohydrolase. This enzyme is also called sorbitol-6-phosphate phosphatase.[5]

References

  1. ↑ Grant CR, ap Rees T (1981). "Sorbitol metabolism by apple seedlings". Phytochemistry. 20 (7): 1505–1511. Bibcode:1981PChem..20.1505G. doi:10.1016/S0031-9422(00)98521-2.
  2. ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "Sorbitol-6-phosphatase". Enzyme Handbook 3. pp. 523–525. doi:10.1007/978-3-642-76463-9_111. ISBN 978-3-642-48962-4.
  3. ↑ Oda, Yasunori; Iwami, Masafumi; Sakurai, Sho (2005). "Membrane-bound sorbitol 6-phosphatase in fat body cells controls the dynamics of sorbitol 6-phosphate, a major hemolymph sugar in the silkworm". Insect Biochemistry and Molecular Biology. 35 (11): 1284–1292. doi:10.1016/j.ibmb.2005.07.002. PMID 16203209.
  4. ↑ Chin, Taejun; Okuda, Yukiko; Ikeuchi, Masahiko (2019). "Improved sorbitol production and growth in cyanobacteria using promiscuous haloacid dehalogenase-like hydrolase". Journal of Biotechnology. 306 100002. doi:10.1016/j.btecx.2019.100002. PMID 34112371.
  5. ↑ Enzyme 3.1.3.50 at KEGG Pathway Database.
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