Simon J Davies

Simon J Davies
Academic background
EducationBSc
MBBS
MD
MA., Music Composition
Alma materUniversity of London
University of Birmingham
Academic work
InstitutionsKeele University

Simon J Davies is a nephrologist and clinical academic. He is an emeritus professor of Nephrology and Dialysis Medicine at Keele University.[1]

Davies' research has focused on peritoneal dialysis, examining peritoneal membrane biology, fluid and solute removal, inflammation, and patient outcomes to optimize long-term PD care. He is a recipient of the 2013 Distinguished International Medal from the American National Kidney Foundation[2] as well as the 2018 Oreopoulos Life-Time Achievement Award from the International Society of Peritoneal Dialysis.[3][4]

Education

Davies completed his BSc in Pharmacology and Basic Medical Sciences in 1978 at King's College London, University of London, followed by an MBBS in 1981 from the same institution. He obtained his MD degree from the University of London in 1989 under the supervision of Stewart Cameron. Additionally, he completed a MA in Music Composition at the University of Birmingham in 2023.[1]

Career

Davies began his academic career in 1989 as a lecturer at Keele University. In 1993, he became a senior lecturer, and was appointed professor in Nephrology and Dialysis Medicine in 2004. Since retirement in 2024, he has been professor emeritus at Keele.[1]

Davies has held several academic and professional appointments. From 2002 to 2006, he worked as clinical director of the Kidney Unit at University Hospital of North Midlands. He was subsequently appointed as the director of the Clinical Research and Health Services Research Unit at Keele from 2010 to 2016, followed by his appointment as director of the Institute for Applied Clinical Sciences, a role he held until 2020. Additionally, he was the president of the International Society of Peritoneal Dialysis from 2010 to 2012. Moreover, since 2023, he is the trustee of Kidney Research UK.[1]

Research

In his early research, Davies showed that differences between individuals in how the peritoneal membrane functions during peritoneal dialysis treatment affect patient survival.[5] Through his work, he demonstrated that this finding was independent of co-existing medical conditions and developed the Stoke–Davies comorbidity score, which was independently validated.[6][7] He also highlighted that reduced fluid removal by the peritoneal membrane, rather than uremic toxins, was a key determinant of five-year survival rates, differing from the prevailing interpretation at the time. He also found that, over time, infections and exposure to glucose-containing dialysis fluid impaired membrane function, contributing to treatment failure.[8] Subsequently, with colleagues, he helped identify three forms of membrane dysfunction affecting fluid removal: rapid glucose absorption associated with local inflammation;[9] an acquired reduction in membrane efficiency due to fibrosis;[10] and a genetically determined reduction in aquaporin pathway expression.[11]

Davies has also investigated ways to measure and evaluate the hydration status of dialysis patients. This included developing a point-of-care measurement of total body water using deuterium dilution with David Smith, evaluating bioimpedance as a measure of body composition, and showing that glucose polymer solutions improve overhydration in peritoneal dialysis.[12] His work has also focused on clinical practices[13] as well as the inequity of access to peritoneal dialysis, highlighting its good outcomes and cost-effectiveness,[14] and the need for future innovation, such as point-of-care dialysis fluid generation.[15]

Awards and honors

  • 2013 – Distinguished International Medal, American National Kidney Foundation[2]
  • 2018 – Oreopoulos Life-time Achievement Award, International Society of Peritoneal Dialysis[3][4]
  • 2023 – Gabor Zellerman Award, International Society for Peritoneal Dialysis[16]

Selected articles

  • Davies, S. J., Phillips, L., Griffiths, A. M., Russell, L. H., Naish, P. F., & Russell, G. I. (1998). What really happens to people on long-term peritoneal dialysis? Kidney International, 54(6), 2207–2217. https://doi.org/10.1046/j.1523-1755.1998.00230.x
  • Davies, S. J., Phillips, L., Naish, P. F., & Russell, G. I. (2001). Peritoneal glucose exposure and changes in membrane solute transport with time on peritoneal dialysis. Journal of the American Society of Nephrology, 12(5), 1046–1051. https://doi.org/10.1681/ASN.V1251046
  • Davies, S. J., Woodrow, G., Donovan, K., Plum, J., Williams, P., Johansson, A. C., Bosselmann, H. P., Heimbürger, O., Simonsen, O., Davenport, A., Tranaeus, A., & Divino Filho, J. C. (2003). Icodextrin improves the fluid status of peritoneal dialysis patients: Results of a double-blind randomized controlled trial. Journal of the American Society of Nephrology, 14, 2338–2344. https://doi.org/10.1097/01.ASN.0000083904.94897.6B
  • Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., Verduijn, M., Dekker, F., Bovy, P., Evenepoel, P., Bammens, B., Selgas, R., Bajo, M. A., Coester, A. M., Sow, A., Hautem, N., Struijk, D. G., Krediet, R. T., Balligand, J.-L., Goffin, E., Crott, R., Ripoche, P., Davies, S., & Devuyst, O. (2021). AQP1 promoter variant, water transport, and outcomes in peritoneal dialysis. New England Journal of Medicine, 385(17), 1570–1580. https://doi.org/10.1056/NEJMoa2034279
  • Davies, S. J., Coyle, D., Lindley, E. J., Keane, D., Belcher, J., Caskey, F. J., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., MacDonald, J., Zanganeh, M., Andronis, L., Solis-Trapala, I., & Sim, J. (2023). Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients: A randomized controlled trial. Kidney International. Advance online publication. https://doi.org/10.1016/j.kint.2023.05.016

References

  1. 1 2 3 4 "Simon J Davies - Academia".
  2. 1 2 "Simon Davies - ISPD". ISPD. Retrieved March 24, 2026.
  3. 1 2 "The CSN Dr. Dimitrios G. Oreopoulos Award".
  4. 1 2 "Oreopoulos Award - ISPD". ISPD. Retrieved March 24, 2026.
  5. ↑ Davies, S. J.; Phillips, L.; Russell, G. I. (April 1998). "Peritoneal solute transport predicts survival on CAPD independently of residual renal function". Nephrology, Dialysis, Transplantation. 13 (4): 962–968. doi:10.1093/ndt/13.4.962. ISSN 0931-0509. PMID 9568858.
  6. ↑ Van Manen, Jeannette G.; Korevaar, Johanna C.; Dekker, Friedo W.; Boeschoten, Elisabeth W.; Bossuyt, Patrick M. M.; Krediet, Raymond T. (February 2003). "Adjustment for comorbidity in studies on health status in ESRD patients: which comorbidity index to use?". Journal of the American Society of Nephrology: JASN. 14 (2): 478–485. doi:10.1097/01.asn.0000043902.30577.c9. ISSN 1046-6673. PMID 12538750.
  7. ↑ Davies, Simon J.; Phillips, Louise; Naish, Patrick F.; Russell, Gavin I. (June 2002). "Quantifying comorbidity in peritoneal dialysis patients and its relationship to other predictors of survival". Nephrology, Dialysis, Transplantation. 17 (6): 1085–1092. doi:10.1093/ndt/17.6.1085. ISSN 0931-0509. PMID 12032201.
  8. ↑ Davies, S. J.; Bryan, J.; Phillips, L.; Russell, G. I. (March 1996). "Longitudinal changes in peritoneal kinetics: the effects of peritoneal dialysis and peritonitis". Nephrology, Dialysis, Transplantation. 11 (3): 498–506. doi:10.1093/oxfordjournals.ndt.a027318. ISSN 0931-0509. PMID 8671821.
  9. ↑ Lambie, Mark; Chess, James; Donovan, Kieron L.; Kim, Yong Lim; Do, Jun Young; Lee, Hi Bahl; Noh, Hyunjin; Williams, Paul F.; Williams, Andrew J.; Davison, Sara; Dorval, Marc; Summers, Angela; Williams, John D.; Bankart, John; Davies, Simon J.; Topley, Nicholas (December 2013). "Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival". Journal of the American Society of Nephrology: JASN. 24 (12): 2071–2080. doi:10.1681/ASN.2013030314. ISSN 1533-3450. PMC 3839554. PMID 24009237.
  10. ↑ Davies, Simon J. (December 2004). "Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients". Kidney International. 66 (6): 2437–2445. doi:10.1111/j.1523-1755.2004.66021.x. ISSN 0085-2538. PMID 15569337.
  11. ↑ Morelle, Johann; Marechal, Céline; Yu, Zanzhe; Debaix, Huguette; Corre, Tanguy; Lambie, Mark; Verduijn, Marion; Dekker, Friedo; Bovy, Philippe; Evenepoel, Pieter; Bammens, Bert; Selgas, Rafael; Bajo, Maria A.; Coester, Annemieke M.; Sow, Amadou; Hautem, Nicolas; Struijk, Dirk G.; Krediet, Raymond T.; Balligand, Jean-Luc; Goffin, Eric; Crott, Ralph; Ripoche, Pierre; Davies, Simon; Devuyst, Olivier (21 October 2021). "AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis". The New England Journal of Medicine. 385 (17): 1570–1580. doi:10.1056/NEJMoa2034279. hdl:11370/d17508df-50cf-4546-9c47-4a01a5a0e213. ISSN 1533-4406. PMID 34670044.
  12. ↑ Davies, S.; Spanel, P.; Smith, D. (November 2001). "Rapid measurement of deuterium content of breath following oral ingestion to determine body water". Physiological Measurement. 22 (4): 651–659. doi:10.1088/0967-3334/22/4/301. ISSN 0967-3334. PMID 11761073.
  13. ↑ Perl, Jeffrey; Davies, Simon J.; Lambie, Mark; Pisoni, Ronald L.; McCullough, Keith; Johnson, David W.; Sloand, James A.; Prichard, Sarah; Kawanishi, Hideki; Tentori, Francesca; Robinson, Bruce M. (May 2016). "The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS): Unifying Efforts to Inform Practice and Improve Global Outcomes in Peritoneal Dialysis". Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 36 (3): 297–307. doi:10.3747/pdi.2014.00288. PMC 4881793. PMID 26526049.
  14. ↑ Davies, Simon; Allen, Kerry; Bekker, Hilary; Coyle, David; Dikomitis, Lisa; Damery, Sarah; Fotheringham, James; Hill, Harry; Lambie, Mark; Potts, Jessica; Solis-Trapala, Ivonne; Williams, Iestyn (1 March 2026). Intervening to eliminate the centre-effect variation in home dialysis use: a synopsis of Inter-CEPt, an exploratory sequential mixed-methods study. National Institute for Health and Care Research.
  15. ↑ Davies, Simon (December 2024). "The future of peritoneal dialysis". Clinical Kidney Journal. 17 (Suppl 2): 9–18. doi:10.1093/ckj/sfae277. ISSN 2048-8505. PMC 11581766. PMID 39583141.
  16. ↑ "Awards - Annual Dialysis Conference". annualdialysisconference.org. Retrieved March 23, 2026.
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