Synaptogyrin 3

SYNGR3
Identifiers
Aliases	SYNGR3, synaptogyrin 3
External IDs	OMIM: 603927; MGI: 1341881; GeneCards: SYNGR3
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 1,989,660 bp End 1,994,275 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 24,904,066 bp End 24,908,929 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 superior frontal gyrus Brodmann area 46 orbitofrontal cortex pons primary visual cortex entorhinal cortex dorsolateral prefrontal cortex frontal pole Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell central gray substance of midbrain dorsomedial hypothalamic nucleus nucleus of stria terminalis ventral tegmental area piriform cortex medial dorsal nucleus lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function SH2 domain binding protein N-terminus binding Cellular component cell junction integral component of membrane cytoplasmic vesicle synapse synaptic vesicle membrane neuromuscular junction synaptic vesicle membrane Biological process substantia nigra development positive regulation of transporter activity regulated exocytosis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9143 20974 Ensembl ENSG00000127561 ENSMUSG00000007021 UniProt O43761 Q8R191 RefSeq (mRNA) NM_004209 NM_011522 RefSeq (protein) NP_004200 NP_035652 Location (UCSC) Chr 16: 1.99 – 1.99 Mb Chr 17: 24.9 – 24.91 Mb PubMed search
Wikidata
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Synaptogyrin 3 is a protein that in humans is encoded by the SYNGR3 gene.

Function

This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010].

Further reading

• Belizaire R, Komanduri C, Wooten K, Chen M, Thaller C, Janz R (March 2004). "Characterization of synaptogyrin 3 as a new synaptic vesicle protein". J. Comp. Neurol. 470 (3): 266–81. doi:10.1002/cne.20008. PMID 14755516. S2CID 24574182.
• Peck EG, Holleran KM, Curry AM, Holter KM, Estave PM, Sens JP, et al. (August 2024). "Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits". bioRxiv 10.1101/2024.07.27.605436.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.