SVT-4A1011

SVT-4A1011
Clinical data
Other namesSVT4A1011
Routes of
administration		Oral[1][2]
Drug classLive biotherapeutic product

SVT-4A1011 is a live biotherapeutic product which is under development for the treatment of insomnia.[1][3][4][5][6] It is taken orally.[1] The drug consists of selected bacteria species naturally found in the gastrointestinal tract with potential effects on the gut–brain axis.[1][2] A patent by its developer on methods for improving sleep quality specifically highlights species including Lactobacillus plantarum and Lactobacillus zeae among others.[7] SVT-4A1011 is under development by Servatus Biopharmaceuticals.[1][3][4][6] As of October 2022, it is in phase 1/2 clinical trials for insomnia.[1][3][4][2]

See also

References

  1. 1 2 3 4 5 6 "SVT 4A1011". AdisInsight. 24 October 2022. Retrieved 7 August 2026.
  2. 1 2 3 "A Phase I/II Randomised, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of a Live Biotherapeutic Product (SVT-4A1011) in Adults with Clinically Diagnosed Insomnia". ANZCTR. Retrieved 7 August 2026.
  3. 1 2 3 "Delving into the Latest Updates on SVT-4A1011 with Synapse". Synapse. 8 May 2025. Retrieved 7 August 2026.
  4. 1 2 3 Pribyl AL, Hugenholtz P, Cooper MA (February 2025). "A decade of advances in human gut microbiome-derived biotherapeutics". Nature Microbiology. 10 (2): 301–312. doi:10.1038/s41564-024-01896-3. PMID 39779879.
  5. ↑ Sami T (25 January 2022). "Servatus advances live microbial biotherapeutics after AU$7.5M capital raise". BioWorld. Retrieved 7 August 2026.
  6. 1 2 Recent results for SVT-4A1011 (PDF). Microbiome Movement Drug Development: The 2023 Summit Report, Boston MA (Report). Boston, MA: MicrobiomePost/Clorofilla srl. 2023. Retrieved 7 August 2026. Other LBP candidates have moved further along in the clinical trial pipeline. Samantha Coulson, Head of Clinical Research at Servatus, discussed recent results for SVT4A1011, a microbial consortium designed to treat insomnia. The gut microbiota plays an important role in sleep quality through the gut-brain axis⁵ , and Servatus sought to help patients improve sleep quality with their LBP. In such efforts, Samantha highlighted the importance of preparing measurable metrics of sleep quality, which they accomplished with the SOMFIT.
  7. ↑ WO 2022115907, Finlayson W, "Methods for improving sleep quality", published 1 December 2021, assigned to Servatus Ltd
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