STC3141

STC3141
Clinical data
Other namesSTC-3141; STC314; STC-314
Routes of
administration		Intravenous infusion[1][2]
Drug classExtracellular histone neutralizer
Identifiers
PubChem SID

STC3141 is an extracellular histone neutralizer which is under development for the treatment of sepsis and COVID-19 pneumonia.[1][3][4][2][5][6] It is given by intravenous infusion.[1][2] The drug is a carbohydrate-based polyanion molecule of β-O-methyl cellobiose sulfate sodium salt (mCBS.Na).[4][5][6] It may limit inflammation and organ damage in sepsis by blocking toxic circulating histones in the condition.[6][2] Accordingly, the drug showed preliminary efficacy in reducing sepsis in a phase 2 clinical trial.[6] STC3141 was developed by Griffith University and the Australian National University and is under development by Grand Pharmaceutical Group in China.[1][6] As of January 2026, it is in phase 2 trials, with a phase 3 trial being planned.[1][3][6]

References

  1. 1 2 3 4 5 "STC 314". AdisInsight. 15 May 2025. Retrieved 25 January 2026.
  2. 1 2 3 4 Bellomo R, Patava J, Van Lancker R, Layios N, Peetermans M, Plummer M, et al. (October 2024). "A dose-adjusted, open-label, pilot study of the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis". Pharmacology Research & Perspectives. 12 (5) e70015. doi:10.1002/prp2.70015. PMC 11472796. PMID 39401149.
  3. 1 2 "Delving into the Latest Updates on STC3141 with Synapse". Synapse. 16 May 2025. Retrieved 26 January 2026.
  4. 1 2 Ge Y, Wang C, Yao C, Wang Y, Zheng Y, Luo J, et al. (2023). "STC3141 improves acute lung injury through neutralizing circulating histone in rat with experimentally-induced acute respiratory distress syndrome". Frontiers in Pharmacology. 14 1166814. doi:10.3389/fphar.2023.1166814. PMC 10239964. PMID 37284312.
  5. 1 2 Meara CH, Coupland LA, Kordbacheh F, Quah BJ, Chang CW, Simon Davis DA, et al. (December 2020). "Neutralizing the pathological effects of extracellular histones with small polyanions". Nature Communications. 11 (1) 6408. Bibcode:2020NatCo..11.6408M. doi:10.1038/s41467-020-20231-y. PMC 7744542. PMID 33328478.
  6. 1 2 3 4 5 6 "Researchers May Have Unlocked the Secret to Treating Sepsis". SciTechDaily. 21 January 2026. Retrieved 26 January 2026.
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