Somatostatin receptor 4

SSTR4
Identifiers
Aliases	SSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4
External IDs	OMIM: 182454; MGI: 105372; GeneCards: SSTR4
Gene location (Human) Chr. Chromosome 20 (human) Band 20p11.21 Start 23,035,312 bp End 23,039,237 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 G3|2 73.44 cM Start 148,237,264 bp End 148,238,687 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus right frontal lobe anterior cingulate cortex cerebellar hemisphere right hemisphere of cerebellum Brodmann area 9 amygdala islet of Langerhans hippocampus proper Top expressed in intestinal villus Ileal epithelium perirhinal cortex entorhinal cortex primary visual cortex dentate gyrus of hippocampal formation granule cell CA3 field superior frontal gyrus granulocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding G protein-coupled receptor activity signal transducer activity somatostatin receptor activity peptide binding Cellular component cytoplasm integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger forebrain development cellular response to glucocorticoid stimulus cell migration arachidonic acid metabolic process positive regulation of MAPK cascade negative regulation of cell population proliferation signal transduction somatostatin signaling pathway chemical synaptic transmission positive regulation of ERK1 and ERK2 cascade positive regulation of arachidonic acid secretion negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6754 20608 Ensembl ENSG00000132671 ENSMUSG00000037014 UniProt P31391 P49660 RefSeq (mRNA) NM_001052 NM_009219 RefSeq (protein) NP_001043 NP_033245 Location (UCSC) Chr 20: 23.04 – 23.04 Mb Chr 2: 148.24 – 148.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

Ligands

Agonists

• J-2156
• L-803087
• Mazisotine (LY3556050)
• NNC 26-9100

See also

• Somatostatin receptor

Further reading

• Patel YC (July 1999). "Somatostatin and its receptor family". Frontiers in Neuroendocrinology. 20 (3): 157–198. doi:10.1006/frne.1999.0183. PMID 10433861. S2CID 44720470.
• Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (January 1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 251–255. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
• Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Tol HH, et al. (June 1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Molecular Pharmacology. 43 (6): 894–901. PMID 8100352.
• Yasuda K, Espinosa R, Davis EM, Le Beau MM, Bell GI (September 1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics. 17 (3): 785–786. doi:10.1006/geno.1993.1410. PMID 8244401.
• Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, et al. (September 1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochemical and Biophysical Research Communications. 195 (2): 844–852. doi:10.1006/bbrc.1993.2122. PMID 8373420.
• Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H (September 1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters. 331 (1–2): 53–59. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. S2CID 22557713.
• Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, et al. (February 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–452. doi:10.1006/geno.1993.1088. PMID 8449518.
• Xu Y, Song J, Bruno JF, Berelowitz M (June 1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochemical and Biophysical Research Communications. 193 (2): 648–652. doi:10.1006/bbrc.1993.1673. PMID 8512564.
• Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, et al. (March 1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications. 232 (1): 157–163. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, et al. (June 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, et al. (August 1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation. 27 (8): 639–644. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. S2CID 23503397.
• Sharma K, Patel YC, Srikant CB (January 1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Molecular Endocrinology. 13 (1). Baltimore, Md.: 82–90. doi:10.1210/mend.13.1.0220. PMID 9892014.
• Forssell-Aronsson EB, Nilsson O, Bejegård SA, Kölby L, Bernhardt P, Mölne J, et al. (April 2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". Journal of Nuclear Medicine. 41 (4): 636–642. PMID 10768564.
• Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC (May 2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism. 86 (5): 2161–2169. doi:10.1210/jcem.86.5.7489. PMID 11344221.
• Talme T, Ivanoff J, Hägglund M, Van Neerven RJ, Ivanoff A, Sundqvist KG (July 2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology. 125 (1): 71–79. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
• Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, et al. (September 2001). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica. 26 (3): 175–179. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, et al. (May 2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv. 440 (5): 461–475. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.

External links

• "Somatostatin Receptors: sst₄". The International Union of Basic and Clinical Pharmacology, The British Pharmacological Society, The University of Edinburgh. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
• somatostatin+receptor+subtype-4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.