Somatostatin receptor 3

SSTR3
Identifiers
Aliases	SSTR3, SS-3-R, SS3-R, SS3R, SSR-28, Somatostatin receptor 3
External IDs	OMIM: 182453; MGI: 98329; GeneCards: SSTR3
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 37,204,237 bp End 37,212,477 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E1|15 37.55 cM Start 78,421,208 bp End 78,428,885 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell islet of Langerhans prefrontal cortex right frontal lobe dorsolateral prefrontal cortex Brodmann area 9 occipital lobe primary visual cortex right testis left testis Top expressed in islet of Langerhans lumbar subsegment of spinal cord dentate gyrus of hippocampal formation granule cell subdivision of hippocampus primary motor cortex Region I of hippocampus proper primary visual cortex hippocampus proper superior frontal gyrus prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding signal transducer activity protein binding somatostatin receptor activity signaling receptor binding G protein-coupled receptor activity peptide binding Cellular component cytoplasm integral component of membrane membrane integral component of plasma membrane cilium neuron projection plasma membrane ciliary membrane non-motile cilium Biological process cell-cell signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cellular response to estradiol stimulus cerebellum development cellular response to glucocorticoid stimulus spermatogenesis response to starvation hormone-mediated apoptotic signaling pathway forebrain development signal transduction negative regulation of cell population proliferation chemical synaptic transmission somatostatin signaling pathway neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6753 20607 Ensembl ENSG00000278195 ENSMUSG00000044933 UniProt P32745 P30935 RefSeq (mRNA) NM_001051 NM_001278687 NM_009218 NM_001356961 RefSeq (protein) NP_001042 NP_001265616 NP_033244 NP_001343890 Location (UCSC) Chr 22: 37.2 – 37.21 Mb Chr 15: 78.42 – 78.43 Mb PubMed search
Wikidata
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Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.

Ligands

Agonists

• L-796778

Antagonists

• BN-81674
• MK-1421
• MK-4256

See also

• Somatostatin receptor

Further reading

• Yamada Y, Reisine T, Law SF, Ihara Y, Kubota A, Kagimoto S, et al. (December 1992). "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase". Molecular Endocrinology. 6 (12). Baltimore, Md.: 2136–2142. doi:10.1210/mend.6.12.1337145. PMID 1337145. S2CID 28499704.
• Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (January 1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 251–255. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
• Corness JD, Demchyshyn LL, Seeman P, Van Tol HH, Srikant CB, Kent G, et al. (April 1993). "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides". FEBS Letters. 321 (2–3): 279–284. doi:10.1016/0014-5793(93)80124-D. PMID 8097479.
• Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J, et al. (April 1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Molecular Pharmacology. 45 (4): 587–590. PMID 8183236.
• Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H (September 1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters. 331 (1–2): 53–59. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.
• Sharma K, Patel YC, Srikant CB (December 1996). "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3". Molecular Endocrinology. 10 (12). Baltimore, Md.: 1688–1696. doi:10.1210/mend.10.12.8961277. PMID 8961277.
• Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, et al. (March 1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications. 232 (1): 157–163. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (June 1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". The Journal of Clinical Endocrinology and Metabolism. 82 (6): 1857–1862. doi:10.1210/jcem.82.6.4013. PMID 9177396. S2CID 25337792.
• de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, et al. (June 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Roth A, Kreienkamp HJ, Meyerhof W, Richter D (September 1997). "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization". The Journal of Biological Chemistry. 272 (38): 23769–23774. doi:10.1074/jbc.272.38.23769. PMID 9295322.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC (May 2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism. 86 (5): 2161–2169. doi:10.1210/jcem.86.5.7489. PMID 11344221.
• Talme T, Ivanoff J, Hägglund M, Van Neerven RJ, Ivanoff A, Sundqvist KG (July 2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology. 125 (1): 71–79. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
• Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, et al. (September 2001). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica. 26 (3): 175–179. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, et al. (May 2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv. 440 (5): 461–475. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.
• Ferone D, Pivonello R, Van Hagen PM, Dalm VA, Lichtenauer-Kaligis EG, Waaijers M, et al. (November 2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. Endocrinology and Metabolism. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335.
• Pasquali D, Notaro A, Bonavolonta' G, Vassallo P, Bellastella A, Sinisi AA (November 2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". The Journal of Clinical Endocrinology and Metabolism. 87 (11): 5125–5129. doi:10.1210/jc.2002-020790. PMID 12414882.
• Dizeyi N, Konrad L, Bjartell A, Wu H, Gadaleanu V, Hansson J, et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology. 7 (3): 91–98. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541.

External links

• "Somatostatin Receptors: sst₃". The International Union of Basic and Clinical Pharmacology, The British Pharmacological Society, The University of Edinburgh. International Union of Basic and Clinical Pharmacology.
• somatostatin+receptor+3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.