SPPL3

SPPL3
Identifiers
Aliases	SPPL3, IMP2, MDHV1887, PRO4332, PSH1, PSL4, UNQ1887, signal peptide peptidase like 3
External IDs	OMIM: 608240; MGI: 1891433; GeneCards: SPPL3
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 120,762,510 bp End 120,904,358 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 115,149,196 bp End 115,236,849 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg mucosa of ileum nipple skin of abdomen skin of thigh skin of hip secondary oocyte mucosa of esophagus human penis Top expressed in cumulus cell corneal stroma Ileal epithelium lip hair follicle CA3 field conjunctival fornix perirhinal cortex entorhinal cortex ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity aspartic-type endopeptidase activity aspartic endopeptidase activity, intramembrane cleaving peptidase activity protein binding hydrolase activity Cellular component integral component of membrane rough endoplasmic reticulum Golgi apparatus endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle integral component of cytoplasmic side of endoplasmic reticulum membrane plasma membrane endoplasmic reticulum Golgi-associated vesicle membrane integral component of lumenal side of endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane lysosomal membrane Biological process positive regulation of protein dephosphorylation membrane protein proteolysis positive regulation of cytosolic calcium ion concentration proteolysis membrane protein ectodomain proteolysis positive regulation of protein binding T cell receptor signaling pathway positive regulation of calcineurin-NFAT signaling cascade signal peptide processing Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 121665 74585 Ensembl ENSG00000157837 ENSMUSG00000029550 UniProt Q8TCT6 Q9CUS9 RefSeq (mRNA) NM_139015 NM_029012 RefSeq (protein) NP_620584 NP_083288 Location (UCSC) Chr 12: 120.76 – 120.9 Mb Chr 5: 115.15 – 115.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Signal peptide peptidase-like 3 is an enzyme that in humans is encoded by the gene SPPL3. This enzyme acts as an intramembrane protease, and is involved in T-cell receptor signaling.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Weihofen A, Binns K, Lemberg MK, et al. (2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. Bibcode:2002Sci...296.2215W. doi:10.1126/science.1070925. PMID 12077416. S2CID 45633906.
• Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI (2003). "Novel class of polytopic proteins with domains associated with putative protease activity". Biochemistry Mosc. 67 (7): 826–35. doi:10.1023/A:1016365227942. PMID 12139484. S2CID 11785597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Friedmann E, Lemberg MK, Weihofen A, et al. (2005). "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins". J. Biol. Chem. 279 (49): 50790–8. doi:10.1074/jbc.M407898200. hdl:2262/89311. PMID 15385547.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Krawitz P, Haffner C, Fluhrer R, et al. (2006). "Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3". J. Biol. Chem. 280 (47): 39515–23. doi:10.1074/jbc.M501645200. PMID 15998642.
• Nyborg AC, Ladd TB, Jansen K, et al. (2006). "Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase". FASEB J. 20 (10): 1671–9. doi:10.1096/fj.06-5762com. PMID 16873890. S2CID 8233317.