GABA transporter type 3

SLC6A11
Identifiers
Aliases	SLC6A11, GAT-3, GAT3, GAT4, solute carrier family 6 member 11
External IDs	OMIM: 607952; MGI: 95630; GeneCards: SLC6A11
Gene location (Human)
Chr.	Chromosome 3 (human)
End	10,940,714 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	114,226,913 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; hypothalamus; ; nucleus accumbens; ; substantia nigra; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; dorsolateral prefrontal cortex; ; gonad;
	Top expressed in
	lumbar subsegment of spinal cord; ; mammillary body; ; dorsomedial hypothalamic nucleus; ; suprachiasmatic nucleus; ; central gray substance of midbrain; ; globus pallidus; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus; ; neural layer of retina; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity; neurotransmitter binding; neurotransmitter:sodium symporter activity; transporter activity; gamma-aminobutyric acid:sodium symporter activity;
Cellular component	cell projection; plasma membrane; membrane; cytoplasm; integral component of membrane; integral component of plasma membrane; synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; neuron projection;
Biological process	brain development; transmembrane transport; neurotransmitter transport; gamma-aminobutyric acid transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6538
	243616
	ENSG00000132164
	ENSMUSG00000030307
	P48066
	P31650
	NM_014229; NM_001317406
	NM_172890
	NP_001304335; NP_055044
	NP_766478
	Wikidata
View/Edit Human	View/Edit Mouse

GABA transporter type 3 (GAT3) uses sodium (Na⁺) electrochemical gradients to mediate uptake of GABA from the synaptic cleft by surrounding glial cells.^[5]

Subtype-selective GAT3 inhibitors are known since 2015.^[6]

The transporter and its effect on GABA concentrations in the amygdala has been implicated as a key player in the disease of alcoholism. In studies conducted on rat populations, reduction of GAT3 caused rats who formerly preferred sugar to prefer alcohol. Further, studies of deceased alcoholics show a decreased concentration of GAT3 in their brains.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132164 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030307 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ (2013). Principles of Neural Science (Fifth ed.). McGraw-Hill Companies. p. 296. ISBN 978-0-07-139011-8.
↑ Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP (2015). "Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3". ACS Chem Neurosci. 6 (9): 1591–9. doi:10.1021/acschemneuro.5b00150. PMID 26154082.
↑ "A Landmark Study on the Origins of Alcoholism". 21 June 2018.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132164 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ (2013). Principles of Neural Science (Fifth ed.). McGraw-Hill Companies. p. 296. ISBN 978-0-07-139011-8.

[pmid26154082-6] Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP (2015). "Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3". ACS Chem Neurosci. 6 (9): 1591–9. doi:10.1021/acschemneuro.5b00150. PMID 26154082.

[7] "A Landmark Study on the Origins of Alcoholism". 21 June 2018.

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See also

References