S-succinylglutathione hydrolase
| S-succinylglutathione hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.2.13 | ||||||||
| CAS no. | 50812-22-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme S-succinylglutathione hydrolase (EC 3.1.2.13) catalyzes the reaction
The enzyme characterised from human liver hydrolyses S-succinylglutathione to glutathione and succinic acid, which forms the thioester in the starting material.[1][2][3]
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name is S-succinylglutathione hydrolase.[4]
References
- ↑ Uotila L (September 1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases". Biochemistry. 12 (20): 3938–43. doi:10.1021/bi00744a024. PMID 4200890.
- ↑ Uotila L (August 1979). "Purification and properties of S-succinylglutathione hydrolase from human liver". The Journal of Biological Chemistry. 254 (15): 7024–9. doi:10.1016/S0021-9258(18)50278-7. PMID 457667.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "S-Succinylglutathione hydrolase". Enzyme Handbook 3. pp. 269–271. doi:10.1007/978-3-642-76463-9_60. ISBN 978-3-642-48962-4.
- ↑ Enzyme 3.1.2.13 at KEGG Pathway Database.
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