S-methyl-5'-thioadenosine deaminase
| S-methyl-5'-thioadenosine deaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.4.31 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
S-methyl-5'-thioadenosine deaminase (EC 3.5.4.31, MTA deaminase, 5-methylthioadenosine deaminase) is an enzyme with systematic name S-methyl-5'-thioadenosine amidohydrolase.[1] This enzyme catalyses the following hydrolysis reaction, giving ammonia as a byproduct:
The enzyme from Thermotoga maritima also functions as an S-adenosylhomocysteine deaminase.[2] In Pseudomonas aeruginosa this is the first step in the catabolism of 5′-methylthioadenosine. The product is acted on by S-methyl-5'-thioinosine phosphorylase to give S-methyl-5-thio-α-D-ribose 1-phosphate and hypoxanthine.[3]
References
- ↑ Enzyme 3.5.4.31 at KEGG Pathway Database.
- ↑ Hermann JC, Marti-Arbona R, Fedorov AA, Fedorov E, Almo SC, Shoichet BK, Raushel FM (August 2007). "Structure-based activity prediction for an enzyme of unknown function". Nature. 448 (7155): 775–9. Bibcode:2007Natur.448..775H. doi:10.1038/nature05981. PMC 2254328. PMID 17603473.
- ↑ Guan R, Ho MC, Almo SC, Schramm VL (February 2011). "Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing". Biochemistry. 50 (7): 1247–54. doi:10.1021/bi101642d. PMC 3040260. PMID 21197954.
External links
- S-methyl-5'-thioadenosine+deaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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