RXYLT1

RXYLT1
Identifiers
Aliases	RXYLT1, HP10481, MDDGA10, transmembrane protein 5, ribitol xylosyltransferase 1, TMEM5
External IDs	OMIM: 605862; MGI: 2384919; GeneCards: RXYLT1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	63,809,792 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; caput epididymis; ; optic nerve; ; lactiferous duct; ; glutes; ; pericardium; ; tail of epididymis; ; renal medulla; ; tibia; ; Skeletal muscle tissue of biceps brachii;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	ribitol beta-1,4-xylosyltransferase activity; transferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; integral component of plasma membrane; membrane; nucleoplasm;
Biological process	protein glycosylation; protein O-linked mannosylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10329
	216395
	ENSG00000118600
	n/a
	Q9Y2B1
	Q8VDX6
	NM_001278237; NM_014254
	NM_153059; NM_001364706
	NP_001265166; NP_055069
	NP_694699; NP_001351635
	Wikidata
View/Edit Human	View/Edit Mouse

Ribitol-5-phosphate xylosyltransferase is an enzyme encoded by RXYLT1 gene.^[4]

Gene

RXYLT1 is located on the long arm (q) of chromosome 12 on position 14.2, from base pair 63,779,833 to base pair 63,809,792.^[5]^[6]

This enzyme is located in the golgi apparatus, and serves as a ribitol b1,4-xylosyltransferase for dystroglycan.^[7]

1 2 3 GRCh38: Ensembl release 89: ENSG00000118600 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entry - *605862 - Ribitol Xylosyltransferase 1; RXYLT1 - OMIM". omim.org. Archived from the original on 2025-04-05. Retrieved 2026-07-27.
↑ "Genome browser — Ensembl". beta.ensembl.org. Retrieved 2026-07-27.
↑ "Gene symbol report | HUGO Gene Nomenclature Committee". www.genenames.org. Retrieved 2026-07-27.
↑ Aso S, Lowe M, Mori K, Ninagawa S (June 2025). "Systematic and comprehensive analysis of major localizations of alpha-dystroglycan-specific modifying enzymes". Glycobiology. 35 (7) cwaf027. doi:10.1093/glycob/cwaf027. hdl:20.500.14094/0100496300. PMID 40324206.