Quercetin 3-O-methyltransferase
| Quercetin 3-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.76 | ||||||||
| CAS no. | 75603-21-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Quercetin 3-O-methyltransferase (EC 2.1.1.76) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the flavonol, quercetin, is converted to 3-O-methylquercetin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).[1][2][3]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase. Other names in common use include flavonol 3-O-methyltransferase, and flavonoid 3-methyltransferase.[4]
References
- ↑ De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases". Arch. Biochem. Biophys. 238 (2): 596–605. doi:10.1016/0003-9861(85)90205-X. PMID 3994393.
- ↑ De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases". Arch. Biochem. Biophys. 238 (2): 606–18. doi:10.1016/0003-9861(85)90206-1. PMID 3994394.
- ↑ Ibrahim RK; De Luca V (1982). "Polymethylated flavonol synthesis is catalyzed by distinct O-methyltransferases". Naturwissenschaften. 69 (1): 41–42. Bibcode:1982NW.....69...41I. doi:10.1007/BF00441101.
- ↑ Enzyme 2.1.1.76 at KEGG Pathway Database.