Putrescine N-methyltransferase
| Putrescine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.53 | ||||||||
| CAS no. | 9075-39-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which putrescine is converted to N-methylputrescine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:putrescine N-methyltransferase. This enzyme is also called putrescine methyltransferase. This enzyme participates in alkaloid biosynthesis ii.[2]
This enzyme is important in the synthesis of many plant alkaloids.[3] It evolved from spermidine synthase.[4]
References
- ↑ Mizusaki S, Tanabe Y, Noguchi M, Tamaki E (1971). "Phytochemical studies on tobacco alkaloids. XIV. The occurrence and properties of putrescine N-methyltransferase in tobacco roots". Plant Cell Physiol. 12: 633–640.
- ↑ Enzyme 2.1.1.53 at KEGG Pathway Database.
- ↑ Biastoff S, Brandt W, Dräger B (2009-10-01). "Putrescine N-methyltransferase--the start for alkaloids". Phytochemistry. Evolution of Metabolic Diversity. 70 (15–16): 1708–18. Bibcode:2009PChem..70.1708B. doi:10.1016/j.phytochem.2009.06.012. PMID 19651420.
- ↑ Junker A, Fischer J, Sichhart Y, Brandt W, Dräger B (2013-01-01). "Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase". Frontiers in Plant Science. 4: 260. Bibcode:2013FrPS....4..260J. doi:10.3389/fpls.2013.00260. PMC 3725402. PMID 23908659.
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