Pravibismane

Pravibismane
Clinical data
Other names	BisEDT
Identifiers
	IUPAC name 2-[2-(1,3,2-dithiabismolan-2-ylsulfanyl)ethylsulfanyl]-1,3,2-dithiabismolane;
CAS Number	175880-68-9;
PubChem CID	10327332;
DrugBank	DB17784;
ChemSpider	52084471;
UNII	G3T79NDD38;
Chemical and physical data
Formula	C6H12Bi2S6
Molar mass	694.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CS[Bi](S1)SCCS[Bi]2SCCS2;
	InChI InChI=1S/3C2H6S2.2Bi/c33-1-2-4;;/h33-4H,1-2H2;;/q;;;2*+3/p-6; Key:GUTNLKRPYCTIHX-UHFFFAOYSA-H;

Pravibismane (BisEDT) is an experimental antibiotic medication for topical use. It is in clinical trials for infections secondary to diabetic foot ulcer.^[1]^[2]

References

↑ Baker B (December 2020). "1289. Pravibismane is a Potent, Broad Spectrum Anti-Infective Small Molecule that Rapidly Disrupts Bacterial Bioenergetics and Halts Bacterial Growth". Open Forum Infectious Diseases. 7 (Suppl 1): S659–S660. doi:10.1093/ofid/ofaa439.1472. PMC 7776586.
↑ Lipsky BA, Kim PJ, Murphy B, McKernan PA, Armstrong DG, Baker BH (April 2024). "Topical pravibismane as adjunctive therapy for moderate or severe diabetic foot infections: A phase 1b randomized, multicenter, double-blind, placebo-controlled trial". International Wound Journal. 21 (4) e14817. doi:10.1111/iwj.14817. PMC 10988878. PMID 38567778.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1] Baker B (December 2020). "1289. Pravibismane is a Potent, Broad Spectrum Anti-Infective Small Molecule that Rapidly Disrupts Bacterial Bioenergetics and Halts Bacterial Growth". Open Forum Infectious Diseases. 7 (Suppl 1): S659–S660. doi:10.1093/ofid/ofaa439.1472. PMC 7776586.

[pmid38567778-2] Lipsky BA, Kim PJ, Murphy B, McKernan PA, Armstrong DG, Baker BH (April 2024). "Topical pravibismane as adjunctive therapy for moderate or severe diabetic foot infections: A phase 1b randomized, multicenter, double-blind, placebo-controlled trial". International Wound Journal. 21 (4) e14817. doi:10.1111/iwj.14817. PMC 10988878. PMID 38567778.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1]

[2]