Pharmacokinetics simulation

Pharmacokinetics simulation is a simulation method used in determining the safety levels of a drug during its development.[1]

Purpose

Pharmacokinetics simulation gives an insight to drug efficacy and safety before exposure of individuals to the new drug that might help to improve the design of a clinical trial. Pharmacokinetics simulations help in addition in therapy planning, to stay within the therapeutic range under various physiological and pathophysiological conditions, e.g., chronic kidney disease.[2]

Simulators

Simcyp Simulator and GastroPlus (from Simulations Plus) are simulators that take account for individual variabilities. PharmaCalc v02 and PharmaCalcCL allow to simulate individual plasma-concentration time curves based on (published) pharmacokinetic parameters such as half-life, volume of distribution etc.

References

  1. ↑ "Physiology-based pharmacokinetic modeling: ready to be used".{{cite web}}: CS1 maint: url-status (link)
  2. ↑ "Physiologically based pharmacokinetic modeling of small molecules: How much progress have we made?".{{cite web}}: CS1 maint: url-status (link)
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