Peter L. Choyke

Peter L. Choyke
Known forMolecular imaging
Prostate cancer imaging
Translational imaging research
AwardsNational Academy of Medicine (elected 2020)
Academic background
Alma materPennsylvania State University
Jefferson Medical College
Academic work
DisciplineRadiology
Molecular imaging
Oncologic imaging
InstitutionsNational Cancer Institute
National Institutes of Health

Peter L. Choyke is an American radiologist and physician-scientist specializing in molecular imaging and oncologic imaging. He is Chief of the Molecular Imaging Branch in the Center for Cancer Research at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and serves as a Senior Investigator with tenure. Choyke is an elected member of the National Academy of Medicine.

Career

Choyke joined the faculty of Georgetown University Hospital in 1984 rising to the rank of Associate Professor of Radiology. Choyke joined the National Institutes of Health in 1987 as a Senior Staff Radiologist. He served as Chief of Clinical MRI from 1992 to 2003 and became Chief of the Molecular Imaging Branch at the National Cancer Institute in 2003. He holds the title of Senior Investigator with tenure at the NIH.[1]

In addition to his roles at the NIH, Choyke has held academic appointments as professor of Radiology at the Uniformed Services University of the Health Sciences and previously served as assistant and associate professor of Radiology at Georgetown University Hospital.[1]

Research

Choyke's research has focused on the development and clinical translation of molecular imaging techniques for cancer detection, characterization, and treatment monitoring.[2] His work integrates advanced imaging modalities, including magnetic resonance imaging (MRI), positron emission tomography (PET), and optical imaging, with targeted molecular probes designed to visualize specific cellular and biochemical processes in vivo.[2][3]

A major area of his research has been imaging of prostate cancer and other genitourinary malignancies.[4] He has contributed to the refinement of multiparametric MRI of the prostate and has participated in national and international efforts to standardize prostate MRI interpretation, including involvement in the development of PI-RADS guidelines.[5][6] His research has also explored MRI-Ultrasound fusion biopsy and focal therapy techniques.[7][8] His work led to the development of the UroNav device.[9]

With his colleague, Hisataka Kobayashi, Choyke helped develop photoimmunotherapy in which an antibody is conjugate to a specific silica phthalocyanine dye (IR700).[10] After injection into a subject and accumulation within a tumor, near infrared light causes activation of the conjugate resulting in cell death and a strong host immune response.[11][12] This treatment method is approved in Japan and over 700 patients have undergone treatment there.[13][14]

Choyke has also been involved in the development of targeted imaging agents and nanoparticle-based platforms designed for use with MRI and radioisotope imaging.[15][16] His current work focuses on radiolabeled compounds for PET imaging and theranostic agents.[2][17]

In addition to probe development, Choyke's laboratory has investigated advanced imaging technologies, including computer-aided cancer detection,[18] diffusion-weighted imaging,[4] and time-of-flight PET systems. His work has emphasized collaboration between imaging scientists, chemists, engineers, and clinicians to facilitate translation from preclinical models to human studies.[2]

Selected awards and honors

References

  1. 1 2 "Peter L. Choyke, M.D., F.A.C.R. | Principal Investigators". NIH Intramural Research Program.
  2. 1 2 3 4 "Peter L. Choyke, M.D., F.A.C.R." Center for Cancer Research. National Cancer Institute. Retrieved 4 June 2026.
  3. ↑ Kobayashi, Hisataka; Ogawa, Mikako; Alford, Raphael; Choyke, Peter L.; Urano, Yasuteru (2010). "New strategies for fluorescent probe design in medical diagnostic imaging". Chemical Reviews. 110 (5): 2620–2640. Bibcode:2010ChRv..110.2620K. doi:10.1021/cr900263j. PMC 3241938. PMID 20000749.
  4. 1 2 Sankineni, Sandeep; Osman, Murat; Choyke, Peter L. (2014). "Functional MRI in prostate cancer detection". BioMed Research International. 2014 590638. doi:10.1155/2014/590638. PMC 4158139. PMID 25215284.
  5. ↑ Weinreb, Jeffrey C.; Barentsz, Jelle O.; Choyke, Peter L.; et al. (2016). "PI-RADS Prostate Imaging – Reporting and Data System: 2015, Version 2". European Urology. 69 (1): 16–40. doi:10.1016/j.eururo.2015.08.052. PMC 6467207. PMID 26427566.
  6. ↑ Barentsz, Jelle O.; Weinreb, Jeffrey C.; Verma, Sadhna; Choyke, Peter L.; et al. (2016). "Synopsis of the PI-RADS v2 Guidelines for Multiparametric Prostate Magnetic Resonance Imaging and Recommendations for Use". European Urology. 69 (1): 41–49. doi:10.1016/j.eururo.2015.08.038. PMC 6364687. PMID 26361169.
  7. ↑ Siddiqui, Mohammad Minhaj; Rais-Bahrami, Soroush; Turkbey, Baris; Choyke, Peter L.; et al. (2015). "Comparison of MR/Ultrasound Fusion-Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer". JAMA. 313 (4): 390–397. doi:10.1001/jama.2014.17942. PMC 4572575. PMID 25626035.
  8. ↑ Mehralivand, Sherif; George, Arvin K.; Hoang, Anthony N.; Choyke, Peter L.; et al. (2021). "MRI-guided focal laser ablation of prostate cancer: a prospective single-arm, single-center trial with 3 years of follow-up". Diagnostic and Interventional Radiology. 27 (3): 394–400. doi:10.5152/DIR.2021.20095. PMC 8136525. PMID 34003127.
  9. ↑ "Precise Clinical Imaging of Tumors". Center for Cancer Research. National Cancer Institute. Retrieved 4 June 2026.
  10. ↑ Mitsunaga, Makoto; Ogawa, Mikako; Kosaka, Nobuyuki; Rosenblum, Leo T.; Choyke, Peter L.; Kobayashi, Hisataka (2011). "Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules". Nature Medicine. 17 (12): 1685–1691. Bibcode:2011NatMe..17.1685M. doi:10.1038/nm.2554. PMC 3233641. PMID 22057348.
  11. ↑ Kobayashi, Hisataka; Choyke, Peter L. (2019). "Near-Infrared Photoimmunotherapy of Cancer". Accounts of Chemical Research. 52 (8): 2332–2339. doi:10.1021/acs.accounts.9b00273. PMC 6704485. PMID 31335117.
  12. ↑ Maruoka, Yasuhiro; Wakiyama, Hiroaki; Choyke, Peter L.; Kobayashi, Hisataka (2021). "Near infrared photoimmunotherapy for cancers: A translational perspective". eBioMedicine. 70 103501. doi:10.1016/j.ebiom.2021.103501. PMC 8340111. PMID 34332294.
  13. ↑ "Japan approves photoimmunotherapy for head and neck cancer". Center for Cancer Research. National Cancer Institute. 4 November 2020. Retrieved 4 June 2026.
  14. ↑ "Rakuten Medical Japan Commercializes BioBlade Laser WR and BioBlade SideFire Diffuser for Photoimmunotherapy in Japan" (Press release). Rakuten Medical. 9 December 2024. Retrieved 4 June 2026.
  15. ↑ Talanov, Vladimir S.; Regino, Celeste A. S.; Kobayashi, Hisataka; Bernardo, Margaret; Choyke, Peter L.; Brechbiel, Martin W. (2006). "Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging". Nano Letters. 6 (7): 1459–1463. Bibcode:2006NanoL...6.1459T. doi:10.1021/nl060765q. PMID 16834429.
  16. ↑ Kobayashi, Hisataka; Koyama, Yoshinori; Barrett, Tristan; Choyke, Peter L.; et al. (2007). "Multi-Modal Nano-Probes for Radionuclide and 5-color Near Infrared Optical Lymphatic Imaging". ACS Nano. 1 (4): 258–264. doi:10.1021/nn700062z. PMC 2600721. PMID 19079788.
  17. ↑ Miyahira, Andrea K.; et al. (2020). "Meeting report from the Prostate Cancer Foundation PSMA theranostics state of the science meeting". The Prostate. 80 (15): 1273–1296. doi:10.1002/pros.24056. PMC 8442561. PMID 32865839.
  18. ↑ Wang, Shijun; Burtt, Karen; Turkbey, Baris; Choyke, Peter; Summers, Ronald M. (2014). "Computer aided-diagnosis of prostate cancer on multiparametric MRI: a technical review of current research". BioMed Research International. 2014 789561. doi:10.1155/2014/789561. PMC 4267002. PMID 25525604.
  19. ↑ "ACR Fellow" (PDF). ACR.org.
  20. ↑ "ISMRM 2008 Poster Awards". Ismrm.org. Retrieved 13 February 2026.
  21. ↑ Bluemke, David A. (February 2020). "Editor's Recognition Awards". Radiology. 294 (2): 241–242. doi:10.1148/radiol.2019192134. ISSN 0033-8419.
  22. ↑ "Peter L. Choyke". NAM.
  23. ↑ "JNM Editors' Choice Awards for 2021". Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 63 (6): 13N. 1 June 2022. PMID 35649666.
  24. ↑ "The 82nd Annual Meeting of the Japan Radiological Society" (PDF). Japan Convention Services.
  25. ↑ "Directory". Association of American Physicians. Retrieved 13 February 2026.
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