PSME3-interacting protein

PSME3IP1
Identifiers
Aliases	PSME3IP1, C16orf94, CDA018, NIP30, CDA10, family with sequence similarity 192 member A, PIP30, FAM192A, proteasome activator subunit 3 interacting protein 1
External IDs	OMIM: 617766; MGI: 1919637; GeneCards: PSME3IP1
Gene location (Human) Chr. Chromosome 16 (human) Band 16q13 Start 57,152,466 bp End 57,186,116 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C5 Start 95,300,766 bp End 95,328,625 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon monocyte granulocyte right uterine tube left testis ganglionic eminence rectum right testis sural nerve transverse colon Top expressed in zygote tail of embryo Ileal epithelium ventricular zone primary oocyte medial ganglionic eminence neural layer of retina genital tubercle epiblast neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus Biological process negative regulation of protein binding negative regulation of proteasomal protein catabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 80011 102122 Ensembl ENSG00000172775 ENSMUSG00000031774 UniProt Q9GZU8 Q91WE2 RefSeq (mRNA) NM_024946 NM_001354078 NM_001354079 NM_001354080 NM_001354081 NM_001354082 NM_001354083 NM_001354084 NM_001354085 NM_001354086 NM_001354088 NM_001354090 NM_001354091 NM_001354092 NM_001354094 NM_001354097 NM_001354098 NM_001354099 NM_001354100 NM_001354087 NM_001354089 NM_001354095 NM_001354096 NM_001354101 NM_001354102 NM_001354103 NM_028221 NM_001363456 NM_001363457 RefSeq (protein) NP_079222 NP_001341007 NP_001341008 NP_001341009 NP_001341010 NP_001341011 NP_001341012 NP_001341013 NP_001341014 NP_001341015 NP_001341017 NP_001341019 NP_001341020 NP_001341021 NP_001341023 NP_001341026 NP_001341027 NP_001341028 NP_001341029 NP_001341016 NP_001341018 NP_001341024 NP_001341025 NP_001341030 NP_001341031 NP_001341032 NP_082497 NP_001350385 NP_001350386 Location (UCSC) Chr 16: 57.15 – 57.19 Mb Chr 8: 95.3 – 95.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

PSME3-interacting protein (also called NIP30) is a protein that in humans is encoded by the PSME3IP1 gene (previously FAM192A). The PSME3-interacting protein contributes to the association of PSME3 to the 20S proteasome, and is also involved in regulating its activity. In particular, it inhibits the break-down of certain proteasome substrates, and the inhibits the interaction of PSME3 and coilin which promotes an increase in the number of cajal bodies in the nucleus.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.