Pleckstrin homology domain containing A4

PLEKHA4
Identifiers
AliasesPLEKHA4, PEPP1, pleckstrin homology domain containing A4
External IDsOMIM: 607769; MGI: 1916467; GeneCards: PLEKHA4
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

57664

69217

Ensembl

ENSG00000105559

ENSMUSG00000040428

UniProt

Q9H4M7

Q8VC98

RefSeq (mRNA)

NM_001161354
NM_020904

NM_148927
NM_001381849

RefSeq (protein)

NP_001154826
NP_065955

n/a

Location (UCSC)Chr 19: 48.84 – 48.87 MbChr 7: 45.18 – 45.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene.[5]

Function

This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105559 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040428 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: Pleckstrin homology domain containing A4". Retrieved 2017-08-24.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This page is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.