Phospholipase B

Search for
Structures	Swiss-model
Domains	InterPro

phospholipase B1
phospholipase B1
Identifiers
Symbol	PLB1
NCBI gene	151056
HGNC	30041
OMIM	610179
RefSeq	NM_153021
UniProt	Q6P1J6
Other data
Locus	Chr. 2 p23.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

PLB1
Identifiers
Aliases	PLB1, PLB, PLB/LIP, hPLB, phospholipase B1
External IDs	OMIM: 610179; MGI: 1922406; GeneCards: PLB1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	28,644,142 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	32,523,864 bp
RNA expression pattern
	Top expressed in
	monocyte; ; mucosa of ileum; ; blood; ; granulocyte; ; testicle; ; Descending thoracic aorta; ; spleen; ; right coronary artery; ; appendix; ; smooth muscle tissue;
	Top expressed in
	spermatid; ; seminiferous tubule; ; right lung lobe; ; blastocyst; ; skin of abdomen; ; lumbar subsegment of spinal cord; ; esophagus; ; left lung lobe; ; thymus; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	lysophospholipase activity; hydrolase activity; lipase activity; hydrolase activity, acting on ester bonds; phospholipase A2 activity; retinyl-palmitate esterase activity; phospholipase activity;
Cellular component	integral component of membrane; plasma membrane; apical plasma membrane; membrane; brush border membrane;
Biological process	lipid catabolic process; positive regulation of acrosome reaction; phosphatidylcholine acyl-chain remodeling; retinoid metabolic process; lipid metabolism; retinol metabolic process; phospholipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	151056
	665270
	ENSG00000163803
	ENSMUSG00000029134
	Q6P1J6
	Q3TTY0
	NM_001170585; NM_153021
	NM_001081407; NM_030072; NM_172147
	NP_001164056; NP_694566
	NP_001074876; NP_084348; NP_742159
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase B, also known as lysophospholipase, is an enzyme with a combination of both PLA₁ and PLA₂ activities; that is, it can cleave acyl chains from both the sn-1 and sn-2 positions of a phospholipid. In general, it acts on lysolecithin (which is formed by the action of PLA₂ on lecithin).

Phospholipase cleavage sites. An enzyme that displays both PLA₁ and PLA₂ activities is called a **phospholipase B**.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163803 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029134 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Vance JE, Vance DE (14 March 2008). Biochemistry of Lipids, Lipoproteins and Membranes. Elsevier. pp. 312–313. ISBN 978-0-08-055988-9.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163803 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029134 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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See also

References