Phosphatidylinositol transfer protein, alpha

PITPNA
Identifiers
Aliases	PITPNA, HEL-S-36, PI-TPalpha, PITPN, VIB1A, phosphatidylinositol transfer protein alpha
External IDs	OMIM: 600174; MGI: 99887; GeneCards: PITPNA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UW5
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,562,792 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,519,630 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; parotid gland; ; pons; ; lateral nuclear group of thalamus; ; skin of leg; ; skin of abdomen; ; monocyte; ; minor salivary glands; ; prefrontal cortex; ; mucosa of esophagus;
	Top expressed in
	retinal pigment epithelium; ; stroma of bone marrow; ; dentate gyrus of hippocampal formation granule cell; ; pontine nuclei; ; superior frontal gyrus; ; medial vestibular nucleus; ; cerebellar cortex; ; granulocyte; ; ileum; ; jejunum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; phosphatidylcholine transporter activity; phosphatidylinositol transfer activity; phosphatidylcholine binding; phosphatidylinositol binding; phosphatidylglycerol binding; phospholipid transporter activity;
Cellular component	cytoplasm; myelin sheath; extracellular exosome; intracellular anatomical structure; cytosol;
Biological process	visual perception; lipid metabolism; axonogenesis; phospholipid transport; interleukin-12-mediated signaling pathway; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5306
	18738
	ENSG00000174238
	ENSMUSG00000017781
	Q00169
	P53810
	NM_006224
	NM_008850
	NP_006215
	NP_032876
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene.^[5]

Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipids between membranes in vitro (Wirtz, 1991).^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174238 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017781 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hay JC, Martin TF (Jan 1994). "Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion". Nature. 366 (6455): 572–5. doi:10.1038/366572a0. PMID 8255295. S2CID 4348488.
↑ "Entrez Gene: PITPNA phosphatidylinositol transfer protein, alpha".

References

Further reading