Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

PIN4
Identifiers
Aliases	PIN4, EPVH, PAR14, PAR17, peptidylprolyl cis/trans isomerase, NIMA-interacting 4
External IDs	OMIM: 300252; MGI: 1916963; GeneCards: PIN4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EQ3, 1FJD, 3UI4, 3UI5, 3UI6
Enzyme activity
Gene location (Human)
Chr.	X chromosome (human)
End	72,302,926 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	102,127,669 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; gingival epithelium; ; amniotic fluid; ; germinal epithelium; ; buccal mucosa cell; ; hair follicle; ; pancreatic epithelial cell; ; pancreatic ductal cell; ; palpebral conjunctiva; ; kidney tubule;
	Top expressed in
	yolk sac; ; lens; ; epiblast; ; embryo; ; duodenum; ; morula; ; bone marrow; ; urinary bladder; ; embryo; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; double-stranded DNA binding; protein binding; bent DNA binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; RNA binding;
Cellular component	cytoplasm; mitochondrial matrix; spindle; preribosome; nucleolus; extracellular exosome; cytoskeleton; mitochondrion; nucleus;
Biological process	rRNA processing; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5303
	69713
	ENSG00000102309
	ENSMUSG00000079480
	Q9Y237
	Q9CWW6
	NM_001170747; NM_006223
	NM_027181
	NP_001164218; NP_006214
	NP_081457; NP_001352019
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 is an enzyme that in humans is encoded by the PIN4 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102309 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079480 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation". BMC Mol Biol. 7 9. doi:10.1186/1471-2199-7-9. PMC 1420321. PMID 16522211.
↑ Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae". BMC Biol. 5 37. doi:10.1186/1741-7007-5-37. PMC 2031878. PMID 17875217.
↑ "Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)".

Uchida T, Fujimori F, Tradler T, et al. (1999). "Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase". FEBS Lett. 446 (2–3): 278–82. Bibcode:1999FEBSL.446..278U. doi:10.1016/S0014-5793(99)00239-2. PMID 10100858. S2CID 45172611.
Rulten S, Thorpe J, Kay J (1999). "Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases". Biochem. Biophys. Res. Commun. 259 (3): 557–62. Bibcode:1999BBRC..259..557R. doi:10.1006/bbrc.1999.0828. PMID 10364457.
Sekerina E, Rahfeld JU, Müller J, et al. (2000). "NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein". J. Mol. Biol. 301 (4): 1003–17. doi:10.1006/jmbi.2000.4013. PMID 10966801.
Terada T, Shirouzu M, Fukumori Y, et al. (2001). "Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14". J. Mol. Biol. 305 (4): 917–26. doi:10.1006/jmbi.2000.4293. PMID 11162102.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Fujiyama S, Yanagida M, Hayano T, et al. (2002). "Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes". J. Biol. Chem. 277 (26): 23773–80. doi:10.1074/jbc.M201181200. PMID 11960984.
Surmacz TA, Bayer E, Rahfeld JU, et al. (2002). "The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding". J. Mol. Biol. 321 (2): 235–47. doi:10.1016/S0022-2836(02)00615-0. PMID 12144781.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102309 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079480 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16522211-5] Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation". BMC Mol Biol. 7 9. doi:10.1186/1471-2199-7-9. PMC 1420321. PMID 16522211.

[pmid17875217-6] Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae". BMC Biol. 5 37. doi:10.1186/1741-7007-5-37. PMC 2031878. PMID 17875217.

[entrez-7] "Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)".

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[3]

[4]

[5]

[6]

[7]

References

Further reading